Results 71 to 80 of about 25,193 (261)

P2X7 receptor antagonism suppresses epileptiform‐like activity in an inflammation‐primed human iPSC‐derived neuron model of drug‐resistant epilepsy

British Journal of Pharmacology, EarlyView.
Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan, Yitao Wang, Klaus Dinkel, Michael Hamacher, Jochen H. M. Prehn, David C. Henshall, Tobias Engel   +6 more
wiley   +1 more source

In vitro screening of UGT2B10 in silico prioritized putative ligands from drugs used in the pediatric hematopoietic stem cell transplantation setting

Pharmacology Research & Perspectives
UGT2B10 is a phase II drug metabolizing enzyme with limited information on its role in the metabolism of drugs, especially in the pediatric hematopoietic stem cell transplantation setting.
Yahia Bennani, Khalil Ben Hassine, Muhammed Gencaslan, Mary Boudal‐Khoshbeen, Caroline Samer, Marc Ansari, Youssef Daali, Chakradhara Rao Satyanarayana Uppugunduri   +7 more
doaj   +1 more source

Tics as a Presenting Symptom in Catatonia

Movement Disorders Clinical Practice, EarlyView.
Lindsey M. Vogt, Nahid Iseyas, Ashley Warnock, Elia Abi‐Jaoude   +3 more
wiley   +1 more source

Prognostic factors and impact of management strategies for status epilepticus: The STEPPER study in the Emilia‐Romagna region, Italy

Epilepsia, Volume 66, Issue 3, Page 753-767, March 2025.
Abstract Objective The STEPPER (Status Epilepticus in Emilia‐Romagna) study aimed to investigate the clinical characteristics, prognostic factors, and treatment approaches of status epilepticus (SE) in adults of the Emilia‐Romagna region (ERR), Northern Italy.
Lidia Di Vito, Eleonora Matteo, Stefano Meletti, Corrado Zenesini, Giorgia Bernabè, Chiara Bomprezzi, Maria Chiara Casadio, Carlo Alberto Castioni, Edward Cesnik, Carlo Coniglio, Marco Currò‐Dossi, Patrizia De Massis, Elisa Fallica, Irene Florindo, Giada Giovannini, Maria Guarino, Elena Marchesi, Andrea Marudi, Elena Merli, Giulia Monti, Niccolò Orlandi, Elena Pasini, Daniela Passarelli, Rita Rinaldi, Romana Rizzi, Michele Romoli, Mario Santangelo, Valentina Tontini, Giulia Turchi, Mirco Volpini, Andrea Zini, Lucia Zinno, Roberto Michelucci, Luca Vignatelli, Paolo Tinuper, Francesca Bisulli, the STEPPER study group, Emanuele Saverio Cece, Fabio Nobili, Gabriele Ricci, Gloria Stoffella, Maria Tappatà, Stefania Testoni, Anna Zaniboni, Roberto D’Alessandro, Marco Zanello, Yerma Bartolini, Giovanni Bini, Maura Pugliatti, Francesca Ceccaroni, Chiara Leta, Claudia Giorgi, Edoardo Picetti, Alessandro Pignatti, Ilaria Naldi, Marco Russo, Anna Rita Guidi   +56 more
wiley   +1 more source

The phenomenology and treatment response in catatonia: A hospital based descriptive study

Indian Journal of Psychological Medicine, 2017
Background: Literatures regarding clinical symptomatology and treatment response of catatonia are very few. Objective: To assess onset, clinical profile, diagnostic break up, treatment response and outcome in patients diagnosed as Catatonia, reported to ...
Sarada Prasanna Swain, Sushree Sangita Behura, Manoj Kumar Dash   +2 more
doaj   +1 more source

The gut microbiome associated with LGI1‐antibody encephalitis

Epilepsia, EarlyView.
Abstract Objective Autoimmune encephalitis is a cause of brain inflammation characterized by auto‐antibodies, which target cell surface neuronal proteins and lead to neuronal dysfunction. The most common form is associated with auto‐antibodies to leucine‐rich glioma‐inactivated 1 (LGI1) protein, the presentation of which includes frequent focal ...
Edmund Gilbert, Sophie Binks, Valentina Damato, Christopher Uy, Paula Colmenero, Mark Kelly, Mohamed Ibrahim Khalil, Marcus O'Brien, Marcus J Claesson, John F. Cryan, Norman Delanty, Sarosh R. Irani, Gianpiero L. Cavalleri   +12 more
wiley   +1 more source

Prescripción de lorazepam dentro de la caja Costarricense del seguro social

Journal Health NPEPS, 2019
Objetivo: describir la prescripción de lorazepam dentro de la caja Costarricense del seguro social. Método: el estudio es descriptivo y retrospectivo, de enero de 2011 a diciembre de 2015. La investigación consistió en 339,484 prescripciones de lorazepam.
Consuelo María Cubero Alpízar, Ligia Rojas Valenciano, Mauricio Campos Fernández   +2 more
doaj  

Respiratory dysfunction and fatal apnea during pilocarpine‐induced status epilepticus

Epilepsia, EarlyView.
Abstract Objective Status epilepticus (SE) is second only to sudden unexpected death in epilepsy as a cause of seizure‐related mortality. The progression of respiratory dysfunction during experimental SE remains poorly characterized. We investigated how pilocarpine‐induced SE affects respiration in mice.
Chengsan Sun, Rachel Spera, John M. Williamson, Suchitra Joshi, Bhavya Guduru, Harini Ganabady, Jaideep Kapur   +6 more
wiley   +1 more source

Quantitative Analysis of Lorazepam in Pharmaceutical Formulation Through FTIR Spectroscopy

E-Journal of Chemistry, 2012
A Fourier transform infrared (FTIR) spectrophotometric method was development for the rapid, direct measurement of lorazepam in different pharmaceutical products.
Elaheh Konoz, Amir Hossein Mohsen Sarrafi, Marjaneh Samadizadeh, Samaneh Boreiri   +3 more
doaj   +1 more source

A case report of preferential effectiveness of clonazepam over lorazepam in the management of a case of alprazolam withdrawal

Journal of Geriatric Mental Health, 2018
Benzodiazepines (BZDs) remain the mainstay in the management of withdrawal arising out of BZD use disorders. The choice of detoxifying agent is determined by the duration of action and also by the metabolic properties of the drug.
Vrinda Saxena, Robin Victor, Arghya Pal
doaj   +1 more source