Results 91 to 100 of about 134,904 (303)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Book-Review: The Sweet and the Bitter: Death and Dying in J. R. R. Tolkien’s The Lord of the Rings

open access: yesFafnir, 2018
Amendt-Raduege, Amy. The Sweet and the Bitter: Death and Dying in J. R. R. Tolkien’s The Lord of the Rings. Kent State UP, 2017. ISBN 978-1606353059.
Nicholas Dalbey
doaj  

Epic World-Building: Names and Cultures in Dune

open access: yesNames, 2016
Names play a significant role in the development of the characters and cultures of the imaginary worlds envisioned by science fiction and fantasy authors. Rather than creating new languages, as J. R. R.
Kara Kennedy
doaj   +1 more source

Lord of the Mood Rings

open access: yes, 2003
Our main objective is to study the mechanisms by which heat transfer taking place in the human finger will affect the color change in the mood ring. This project uses GAMBIT and FIDAP to model the heat transfer from the finger to the ring. Finding the
Celia, Chan   +3 more
core  

The Horns of the North: Historical Sources of J. R. R. Tolkien\u27s Trilogy [PDF]

open access: yes, 1976
Few books have enjoyed the publishing success seen in the last decade by J. R. R. Tolkien\u27s epic fantasy trilogy, The Lord of the Rings. Since the time of its paperback appearance in 1965 the work has not only attracted wide popular readership but has
Geib, George W.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Ant Similes in J.R.R. Tolkien’s The Lord of the Rings – an Analysis of Literary Technologies

open access: yesFafnir
This article investigates the use of similes in J.R.R. Tolkien’s writing as literary-technological design that partakes in traditional means for narrative meaning-making repurposed for his fantasy in The Lord of the Rings.
Juha-Pekka Alarauhio
doaj  

Open Strategy in a Smart City

open access: yesTechnology Innovation Management Review, 2019
To attract new companies and a talented workforce in a way that increases income streams, cities are searching for strategic capabilities by using a variety of strategic practices.
Suvi Einola   +2 more
doaj   +1 more source

Tolkien\u27s Middle-Earth: Race Personified through Orcs [PDF]

open access: yes, 2015
From the time of Middle-earth’s creation, a complex society of hierarchies has existed both within and among the different races and creatures in Tolkien’s world.
Fessler, Colleen
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

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