Results 91 to 100 of about 135,248 (293)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

WAYS OF TRANSLATING METAPHORS IN J.R.R.TOLKIEN’S “THE LORD OF THE RINGS”

open access: yesStudia Universitatis Moldaviae: Stiinte Umanistice, 2008
Articolul prezent este dedicat studiului contrastiv al traducerii metaforei de către doi translatori V.Muraviov şi V.Motorina în romanul lui J.R.R.Tolkien “Regele inelelor”.
USM ADMIN
doaj  

In Search of Authenticity: the ‘Global Popular’ and ‘Quality’ Culture—the Case of The Lord of the Rings Trilogy and Pavement

open access: yesPORTAL: Journal of Multidisciplinary International Studies, 2005
Through an examination of three special issues devoted to The Lord of the Rings trilogy in Pavement, a New Zealand magazine, I propose to discuss the way in which the representation of these films suggests the complexities of the intersection between the
Hilary Radner
doaj   +1 more source

Tolkien\u27s surrealistic pillow: Leaf by Niggle [PDF]

open access: yes, 2018
This article proposes a link between J.R.R. Tolkien’s autobiographical short story Leaf by Niggle and twentieth century Surrealism. Elements of the story which are suggestive of surrealistic fantasy are discussed, alongside its singular origin and role ...
Organ, Michael
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Ant Similes in J.R.R. Tolkien’s The Lord of the Rings – an Analysis of Literary Technologies

open access: yesFafnir
This article investigates the use of similes in J.R.R. Tolkien’s writing as literary-technological design that partakes in traditional means for narrative meaning-making repurposed for his fantasy in The Lord of the Rings.
Juha-Pekka Alarauhio
doaj  

Book-Review: The Sweet and the Bitter: Death and Dying in J. R. R. Tolkien’s The Lord of the Rings

open access: yesFafnir, 2018
Amendt-Raduege, Amy. The Sweet and the Bitter: Death and Dying in J. R. R. Tolkien’s The Lord of the Rings. Kent State UP, 2017. ISBN 978-1606353059.
Nicholas Dalbey
doaj  

Epic World-Building: Names and Cultures in Dune

open access: yesNames, 2016
Names play a significant role in the development of the characters and cultures of the imaginary worlds envisioned by science fiction and fantasy authors. Rather than creating new languages, as J. R. R.
Kara Kennedy
doaj   +1 more source

Shieldmaiden

open access: yes, 2013
Shieldmaiden is a poem that examines J.R.R. Tolkien\u27s Lord of the Rings series from a feminist perspective, focusing on the character of Éowyn and her influence on female readers of Tolkien\u27s ...
Taylor, Allison A.
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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