Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
The quest for the ukrainian “Araucana”. The case for the humanization of the Orc
Revista Electrónica IberoamericanaThe decade-long armed conflict between Russia and Ukraine (2014-2024) has been characterized legally and politically in different ways, such as a war of self-defense against external aggression to uphold the rules-based international order, or a war of ...
Francisco Lobo
doaj +1 more source
J.R.R. Tolkien: the Forest and the City (2013), edited by Helen Conrad-O’Briain and Gerard Hynes. [PDF]
, 2015 J.R.R. Tolkien: the Forest and the City (2013), edited by Helen Conrad-O’Briain and Gerard Hynes. Book Review by Kelley M.
Wickham-Crowley, Kelley M.
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Il tema della mostruosità in J.R.R. Tolkien
Studi sulla FormazioneThe literary Twentieth Century was marked by a global cultural phenomenon called Fantasy. The progenitor of this narrative vein was undoubtedly John Ronald Reuel Tolkien.
Ivano Sassanelli
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Лексико-стилістичний аналіз втілення образу зла в кінотрилогії «володар кілець» (Lexico-semantic analysis of incarnation of evil in the film trilogy The Lord of the Rings) [PDF]
, 2017 У тезах проаналізовано лексичні та стилістичні засо- би зображення образу зла, виявлені у кінотрилогії «Володар кілець». Основна увага зосереджена на їхньому значенні та функціях.
Мирончук, І. (I. Myronchuk)
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Authorizing Tolkien: Control, Adaptation, and Dissemination of J.R.R. Tolkien\u27s Works [PDF]
, 2016 This article is the introduction to the special theme issue consisting of four essays on Authorizing Tolkien. Reid and Elam discuss medieval and postmodern theories of adaptation and interpretation and introduce the essays in the ...
Elam, Michael D., Reid, Robin A.
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source