Results 1 to 10 of about 1,073 (117)

First-in-human evaluation of a no-alpha interleukin–2 mutein: safety and preliminary pharmacodynamic and clinical effect [PDF]

open access: yesFrontiers in Immunology
IntroductionInterleukin 2 (IL-2) is essential for immune system activation. To reduce toxicity and prevent the activation of regulatory T cells (T-regs), a novel IL-2 variant containing 4-point mutations that prevent its interaction with the alpha chain ...
Iraida Caballero Aguirrechu   +22 more
doaj   +2 more sources

Evaluation of the epidemiological and economic impact of the ADLIFE intervention on medium- to long-term in patients with advanced chronic disease [PDF]

open access: yesFrontiers in Public Health
IntroductionPatients with advanced chronic disease (ACD) experience transitions in their clinical stability, leading to increased healthcare resource use and costs.
Igor Larrañaga   +55 more
doaj   +2 more sources

Herederos: Ponte, García Vega y Casal

open access: yesAnclajes, 2021
En este trabajo me propongo analizar un aspecto puntual en las relaciones literarias entre Antonio José Ponte y Lorenzo García Vega basándome en los ensayos que ambos le dedican a la obra de Julián del Casal.
Ignacio Iriarte
doaj   +13 more sources

Impact of patient safety on hospital prognosis: Association between adverse events and in-hospital mortalit [PDF]

open access: yesClinical Medicine
Introduction: Adverse events (AEs) involve a safety problem and compromise the quality of care, but evidence on how they affect the prognosis of patients is limited.
Miriam Roncal-Redin   +95 more
doaj   +2 more sources

Venous thromboembolism in patients with breast, ovarian, and uterine cancer. A comparative analysis from the Registro Informatizado Enfermedad TromboEmbólica registry [PDF]

open access: yesResearch and Practice in Thrombosis and Haemostasis
Background: The risk of recurrent venous thromboembolism (VTE) and bleeding during anticoagulation may vary by the cancer type. Objectives: We assessed outcomes during anticoagulation in women with breast, ovarian, or uterine cancer and VTE.
Olga Gavín Sebastián   +226 more
doaj   +2 more sources

Swine farm environmental microbiome: exploring microbial ecology and functionality across farms with high and low sanitary status [PDF]

open access: yesFrontiers in Veterinary Science
IntroductionStringent regulations in pig farming, such as antibiotic control and the ban on certain additives and disinfectants, complicate disease control efforts.
Clara Marin   +11 more
doaj   +2 more sources

First year after surgery is the optimal period to define early prosthetic valve endocarditis: a cohort study [PDF]

open access: yesOpen Heart
Background The definition of early prosthetic valve endocarditis (PVE) remains controversial. This study aims to refine the definition of early PVE by analysing data from the Spanish endocarditis registry (Spanish Collaboration on Endocarditis).Methods ...
  +421 more
doaj   +2 more sources

Sos1 ablation alters focal adhesion dynamics and increases Mmp2/9-dependent gelatinase activity in primary mouse embryonic fibroblasts [PDF]

open access: yesCell Communication and Signaling
Background Sos1 and Sos2 are guanine-nucleotide exchange factors for Ras and Rac small GTPases, which are involved in a wide range of cellular responses including proliferation and migration.
Pilar Liceras-Boillos   +13 more
doaj   +2 more sources

Nanopore versus Illumina to study the gut bacterial diversity of sows and piglets between farms with high and low health status [PDF]

open access: yesBMC Veterinary Research
Background Antibiotics are used in animal husbandry to control infectious diseases. Different stressors can compromise animal health, leaving piglets vulnerable to pathogens, especially enterotoxigenic Escherichia coli (ETEC), which causes post-weaning ...
Carla Tort-Miró   +12 more
doaj   +2 more sources

Identification of Antimicrobial-Resistant Zoonotic Bacteria in Swine Production: Implications from the One Health Perspective [PDF]

open access: yesAntibiotics
Antimicrobial resistance poses a major threat to global health and food security and is primarily driven by antimicrobial use in human and veterinary medicine.
Maria Paz Ventero   +12 more
doaj   +2 more sources

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