Alectinib and lorlatinib function by modulating EMT-related proteins and MMPs in NSCLC metastasis
Biomolecules & Biomedicine, 2021 Most advanced non-small cell lung cancer (NSCLC) patients are accompanied by brain metastasis which is the major cause of increased mortality. The fusion rearrangement of anaplastic lymphoma kinase (ALK) gene is an important feature of brain metastasis ...
Xu Feng, En-Shi Xu
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Modular Synthesis of Pyritide‐Inspired Macrocycles Featuring Bipyridine Motifs
Angewandte Chemie, Volume 137, Issue 51, December 15, 2025.A pyritide‐inspired build/couple/pair strategy yields a diverse macrocycle library. This approach expands chemical space and enables the discovery of 6paW, a potent anti‐ferroptotic agent. Abstract Macrocycles represent a promising class of drug‐like scaffolds with unique structural features and the ability to engage challenging targets such as protein–
Ji Hyae Lee +4 more
wiley +2 more sources
Thoracic Cancer, 2023 Background To dynamically monitor the changes of genomic characteristics during lorlatinib treatment and analyze the resistance profile of lorlatinib in ALK‐positive advanced Chinese patients with non‐small cell lung cancer (NSCLC) with first‐ and second‐
Xiya Ma +8 more
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Lorlatinib‐induced visual and auditory hallucinations: A case report
Clinical Case Reports, 2021 Lorlatinib can cause visual and auditory hallucinations. And, it is necessary to keep in mind that hallucinations can persist even after discontinuation in patients who develop hallucinations while receiving lorlatinib.
Jun Hakamata +7 more
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Translational Lung Cancer ResearchBackground Targeted therapy has dramatically altered the treatment paradigm for some patients with inflammatory myofibroblastic tumor (IMT) that possesses specific molecular aberrations. IMT is an exceedingly rare type of sarcoma, with about 50% of cases
Li-Bo Tang +13 more
semanticscholar +1 more source
Novel polymorphs of Lorlatinib and their processes for the preparation thereof [PDF]
, 2020 The present invention provides novel polymorphs of Lorlatinib and their processes for the preparation ...
MSN Laboratories Private Limited, R&D Center
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Novel polymorph of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-4,8-methenopyrazolo[4,3-h][2,5,11]Benzoxadiazacyclo tetradecine-3-carbonitrile and its process for the preparation thereof [PDF]
, 2021 The present invention relates to a novel crystalline polymorph of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-4,8-methenopyrazolo[4,3h] [2,5,11] benzoxadiazacyclotetradecine-3-carbonitrile represented by following ...
, Srinivasan Thirumalai Rajan
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Asia-Pacific Journal of Clinical Oncology, EarlyView.Lung cancer remains Australia's leading cause of cancer death. With new screening and evolving therapies, equitable access and workforce readiness are essential. This review discusses current and emerging treatments for NSCLC in Australia, clinical trials underway, and future directions in delivering optimal, accessible care nationwide.
Lauren Julia Brown +7 more
wiley +1 more source
ALK, ROS1 and EGFR next-generation tyrosine kinase inhibitors in advanced non-small-cell lung cancer [PDF]
, 2019 Non-small-cell lung cancer (NSCLC) is the most common cancer in men and the second most common in fe- males. In previous years the significance of some molecular disorders in pathogenesis NSCLC was proven and the value of targeted therapies in the ...
Krzakowski, Maciej +2 more
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Psychiatric Adverse Reactions to Anaplastic Lymphoma Kinase Inhibitors in Non-Small-Cell Lung Cancer: Analysis of Spontaneous Reports Submitted to the FDA Adverse Event Reporting System [PDF]
, 2022 open7siBackground The development of anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) has improved the survival outcomes of patients with advanced ALK-rearranged non-small-cell lung cancer (NSCLC).
Ardizzoni, Andrea +6 more
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