Results 81 to 90 of about 8,510 (199)

Role of Targeted Therapy and Immune Checkpoint Blockers in Advanced Non-Small Cell Lung Cancer: A Review. [PDF]

, 2019
Advanced non-small cell lung cancer (NSCLC) is a complex disease comprising molecularly distinct tumor types, each with a unique biology that is becoming increasingly better characterized.
Abdel Karim, Nagla, Kelly, Karen
core  

Asymmetric Catalytic Hydrogenation toward a Value‐Added Chiral Building Block: Optically Active γ‐Butyrolactone Scaffold from Renewable and Synthetic Derived Feedstocks

European Journal of Organic Chemistry, Volume 29, Issue 3, January 22, 2026.
This brief compendium summarizes the most successful asymmetric hydrogenation strategies for the preparation of chiral monocyclic γ‐lactone derivatives from keto acids and keto esters, with emphasis on their relevance for large‐scale production and high enatioselectivities. This article provides a brief compendium on the production of chiral monocyclic
Marta Feliz, Maria J. Sabater
wiley   +1 more source

A Case of Lung Adenocarcinoma With Concurrent EGFR Mutation and ALK Fusion Combined With Literature Review

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT This case underscores the critical importance of retesting for resistant mechanisms, such as EML4‐ALK fusion, in patients with EGFR‐mutant lung adenocarcinoma who experience rapid progression on EGFR‐tyrosine kinase inhibitor (TKI) therapy. Early identification of such co‐alterations and an immediate switch to alectinib can lead to rapid and ...
Yuzhu Chen, Fei Qi, Yixin Zeng, Jingwen Tan, Mingming Hu, Hongmei Zhang, Tongmei Zhang   +6 more
wiley   +1 more source

Evaluation of the Effect of Lorlatinib on CYP2B6, CYP2C9, UGT, and P-Glycoprotein Substrates in Patients with Advanced Non-Small Cell Lung Cancer [PDF]

Lorlatinib; Glycoprotein; Advanced non-small cell lung cancerLorlatinib; Glicoproteïna; Càncer de pulmó de cèl·lules no petitesLorlatinib; Glicoproteína; Cáncer de pulmón de células no pequeñasBackground and Objective Lorlatinib is a tyrosine kinase ...
Bauman, J. R., bearz, alessandra, Chen, Joseph, chiari, rita, FELIP, ENRIQUETA, Kim, Dong-Wan, Mamdani, Hirva   +6 more
core   +1 more source

LOREALAUS: LOrlatinib REAL-World AUStralian Experience in Advanced ALK-Rearranged NSCLC

JTO Clinical and Research Reports, 2023
Introduction: Over the past decade, ALK tyrosine kinase inhibitors have delivered unprecedented survival for individuals with ALK-positive (ALK+) lung cancers.
Marliese Alexander, B.Pharm(Hons), MPH, PhD, Joe Wei, MD, Sagun Parakh, MD, Thomas John, MD, Steven Kao, MD, Adnan Nagrial, MD, Samantha Bowyer, MD, Lydia Warburton, MD, Melissa Moore, MD, Brett G.M. Hughes, MD, Timothy D. Clay, MD, Nick Pavlakis, MD, Benjamin J. Solomon, MD, Malinda Itchins, MD   +13 more
doaj   +1 more source

Prognostic Analysis of Lung Cancer With Brain Metastases in Elderly Patients: A Multicenter Retrospective Study

AGING MEDICINE, Volume 8, Issue 6, Page 585-591, December 2025.
Targeted therapy is associated with significantly improved prognosis and longer OS in elderly lung cancer brain metastases patients. And neurosurgical resection, radiotherapy, immunotherapy, and chemotherapy do not significantly affect OS in this patient group.
Anqi Li, Daqin Feng, Chang Liu, Chaojue Huang, Tang Li, Donggui Wei, Fangyi Wei, Muling Shen, Congzhi Qin, Shufang Deng, Hui Liang, Panlin Mo, Minhai Dong, Yongjia Yu, Lun Liang   +14 more
wiley   +1 more source

An improved process for the preparation of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-4,8-methenopyrazolo [4,3-h][2,5,11]Benzoxadiazacyclo tetradecine-3-carbonitrile and its intermediates thereof [PDF]

, 2021
The present invention relates to an improved process for the preparation of (10R)-7-amino-12-fluoro-2,10, 16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-4,8-methenopyrazolo [4,3-h] [2,5,11] benzoxadiazacyclotetradecine-3-carbonitrile of formula-1 and its ...
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core   +1 more source

A Zosteriform Papular Cutaneous Eruption

JEADV Clinical Practice, EarlyView.
Silvia Borriello, Umberto Santaniello, Astrid Lappi, Paolo Borrelli, Angelo Battaglia, Roberta Patetta, Sophie Frassy, Simone Ribero, Pietro Quaglino   +8 more
wiley   +1 more source

Progression and Metastasis of Lung Cancer: Clinical Features, Molecular Mechanisms, and Clinical Managements

MedComm, Volume 6, Issue 12, December 2025.
Lung cancer represents a significant global health threat. Despite progress in treatment, metastasis continues to present a major clinical challenge. This article reviews the metastases of lung cancer to the liver, bone, and brain, focusing on clinical symptoms, molecular mechanisms, and treatment strategies.
Yunkui Zhang, Meixi Chen, Xumeng Fang, Yu Han, Yingke Li   +4 more
wiley   +1 more source

Bilateral optic neuropathy associated with lorlatinib monotherapy for ALK-positive metastatic lung adenocarcinoma. [PDF]

PURPOSE: This report details the characteristics of a case of bilateral optic neuropathy during treatment with oral lorlatinib for ALK-positive metastatic adenocarcinoma of the lung. OBSERVATIONS: A 57-year-old woman with metastatic adenocarcinoma of the
Bonelli, Laura, Engelmann, Alexander, Hosseini, Mahdieh, Kong, Alan   +3 more
core   +1 more source