Results 121 to 130 of about 2,619 (179)

Formulation development of Lornoxicam loaded heat triggered ocular in-situ gel using factorial design

Drug Development and Industrial Pharmacy, 2023
Objective In the current research, lornoxicam-loaded in situ gels were developed, and their potential usage in ocular inflammation was evaluated. Significance Lornoxicam cyclodextrin complex prepared with hydroxypropyl methylcellulose and poloxamer P407 ...
H. Polat, Sedat Ünal, Eren Aytekin, N. F. Karakuyu, Esra Pezik, Muhammet Kerim Haydar, Nihat Kurt, Osman Doğan, Behzad Mokhtare   +8 more
semanticscholar   +1 more source

Epidural lornoxicam administration – innocent

Journal of Clinical Neuroscience, 2007
We aimed to determine the analgesic efficacy and clinical or histopathological neurotoxicity of epidural single-dose lornoxicam. Caudal epidural catheters were inserted into 28 rabbits, divided into four groups, on day 1. Pain latency and degree of motor and sensory loss for each animal for different concentrations of lornoxicam were determined on day ...
Canduz, Basak, Aktug, Huseyin, Mavioglu, Oemuer, Erkin, Yueksel, Yilmaz, Ozlem, Uyanikgil, Yigit, Korkmaz, Huelya, Baka, Meral   +7 more
openaire   +3 more sources

Formulation, Optimization, and Evaluation of Lornoxicam-Loaded Novasomes for Targeted Ulcerative Colitis Therapy: In Vitro and In Vivo Investigations.

Journal of drug targeting (Print)
The purpose of this work was to create and assess Lornoxicam (LOR) loaded Novasomes (Novas) for the efficient treatment of ulcerative colitis. The study was performed using a 23 factorial design to investigate the impact of several formulation variables.
Asmaa Badawy Darwish, Abeer Salama, Inas Essam Ibrahim Al-Samadi   +2 more
semanticscholar   +1 more source

Integration of lornoxicam nanocrystals into hydroxypropyl methylcellulose-based sustained release matrix to form a novel biphasic release system.

International Journal of Biological Macromolecules, 2022
The study aims to (a) enhance the solubility of a poorly soluble drug by optimization of nanocrystal formulation using the top-down approach and (b) modify the release profile of this drug, which exhibits a short elimination half-life, by the integration
Nguyen-Thach Tung, Thi-Hoang-Yen Dong, Cao-Son Tran, T. Nguyen, S. Chi, Danh Dao, D. Nguyen   +6 more
semanticscholar   +1 more source

A tragacanth gum-infused graphitic carbon nitride/cellulose nanohydrogel for controlled lornoxicam release kinetics

New Journal of Chemistry
Hydrogel biomaterials are increasingly utilized as drug delivery systems due to their unique properties.
Aamir Nawaz, M. Taj, Muhammad Imran Khan, Abeer M. Beagan, Antoniadou Maria, A. Shanableh   +5 more
semanticscholar   +1 more source

Comparative Assessment of Amine‐Functionalized KIT‐5 and KIT‐6 Mesoporous Silica as Carriers for Lornoxicam Adsorption and Release

ChemistrySelect
In this research, Mesoporous silica KIT‐5 and KIT‐6 were prepared using template sol–gel method. The synthesized particles were functionalized through post‐grafting method with (3‐Aminopropyl) trimethoxysilane (APTMS) to form (KIT5‐NH2) and (KIT6‐NH2) as
Ali H. Khalbas, T. Albayati, Issam K. Salih, H. S. Majdi   +3 more
semanticscholar   +1 more source

UV-Spectrophotometric Method Development and Determination of Suitable Medium for Lornoxicam by Comparing In-Between Three Body Fluids

Asian Journal of Pharmaceutical Analysis
The study was aimed to create and verify a new, straight-forward, accurate, and specific UV-Spectrophotometric analysis method of Lornoxicam, by comparing in-between three different types of body fluids, having three different pH, like a) gastric fluid ...
Sourav Duari, Ayan Das, R. Pal
semanticscholar   +1 more source

Lipid-chitosan hybrid nanoparticles for transdermal co-delivery of lornoxicam and curcumin in arthritis management.

International Journal of Biological Macromolecules
The transdermal drug delivery system (TDDS) is a promising approach with multiple advantages, including enhanced permeation and improved therapeutic outcomes. In this study, we developed lipid polymer hybrid nanoparticles (LPHNPs) co-loaded with curcumin
Arshad Khan, Asadullah Madni, Nauman Rahim Khan, Nasrullah Jan, Safiullah Khan, Hassan Shah, Muhammad Abdur Rahim, Ashraf Ullah Khan, A. Jabar   +8 more
semanticscholar   +1 more source

A novel soluble lornoxicam-sodium chelate monohydrate with improved plasticity and tabletability.

International journal of pharmaceutics, 2022
Lornoxicam (LOR), a BCS Ⅱ nonsteroidal anti-inflammatory drug, has been clinically utilized for moderate to severe acute pain management. However, it has poor water solubility and insufficient tabletability, leading to erratic absorption and challenge in
Hui Chen, Jingwen Zhang, Qiyang Qiao, Enshi Hu, Yuanfeng Wei, Zunting Pang, Yuan Gao, Shuai Qian, Jianjun Zhang, W. Heng   +9 more
semanticscholar   +1 more source

Intra-articular Injection of Lornoxicam and MicroRNA-140 Co-loaded Cationic Liposomes Enhanced the Therapeutic Treatment of Experimental Osteoarthritis

AAPS PharmSciTech, 2021
Osteoarthritis is a chronic joint disease characterized by chronic inflammation, progressive destruction of articular cartilage, and subchondral bone sclerosis.
Kongfang He, Xiaoyu Huang, R. Shan, Xuehua Yang, Ruonan Song, Fei Xie, Guihua Huang   +6 more
semanticscholar   +1 more source