Results 161 to 170 of about 42,220 (210)

Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-κB and MAPK signaling

Pharmacological Research, 2022
Sepsis-induced cardiomyopathy (SIC) is a serious complication of sepsis with high mortality but no effective treatment. The renin angiotensin (Ang) aldosterone system (RAAS) is activated in patients with sepsis but it is unclear how the Ang II/Ang II ...
Xinsen Chen, Shu-Hang Wang, Chenyang Liu, Yu-lei Gao, Xianglu Meng, Wei Wei, Song-Tao Shou, Yan-Cun Liu, Y. Chai   +8 more
exaly   +2 more sources

Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

Lancet, The, 2002
Sverre E Kjeldsen
exaly   +2 more sources

Oxidative degradation of pharmaceutical losartan potassium with N-doped hierarchical porous carbon and peroxymonosulfate

Chemical Engineering Journal, 2020
Losartan potassium (LOS) is a most globally consumed antihypertensive and emerging pharmaceutical contaminant of concern due to increasingly ubiquity in water and wastewater. For its effective environmental remediation, we propose the catalytic oxidation
Melissa Gurgel Adeodato Vieira
exaly   +2 more sources

Angiotensin receptor blocker Losartan inhibits tumor growth of colorectal cancer

EXCLI Journal : Experimental and Clinical Sciences, 2021
The renin-angiotensin system (RAS) is up-regulated in patients with colorectal cancer (CRC) and is reported to be associated with poor prognosis and chemo-resistance.
M. Hashemzehi, F. Rahmani, Mahdieh Khoshakhlagh, A. Avan, F. Asgharzadeh, F. Barneh, R. Moradi-Marjaneh, Atena Soleimani, Hamid Fiuji, G. Ferns, Mikhail Ryzhikov, Mohieddin Jafari, M. Khazaei, S. M. Hassanian   +13 more
semanticscholar   +1 more source

The Beneficial Effect of an Intra-articular Injection of Losartan on Microfracture-Mediated Cartilage Repair Is Dose Dependent

American Journal of Sports Medicine, 2021
Background: A previous publication demonstrated that the oral intake of losartan promoted microfracture-mediated hyaline-like cartilage repair in osteochondral defects of a rabbit knee model.
Catherine A. Logan, Xueqin Gao, Hajime Utsunomiya, Alex C. Scibetta, Mika Talwar, S. Ravuri, Joseph J. Ruzbarsky, J. Arner, Dandan Zhu, W. Lowe, M. Philippon, J. Huard   +11 more
semanticscholar   +1 more source

Regulating cancer associated fibroblasts with losartan-loaded injectable peptide hydrogel to potentiate chemotherapy in inhibiting growth and lung metastasis of triple negative breast cancer

Biomaterials, 2017
Pengcheng Zhang, Haijun Yu, Zhiwen Zhang
exaly   +2 more sources

Biologically Regulated Marrow Stimulation by Blocking TGF-β1 With Losartan Oral Administration Results in Hyaline-like Cartilage Repair: A Rabbit Osteochondral Defect Model

American Journal of Sports Medicine, 2020
Background: Microfracture or bone marrow stimulation (BMS) is often the first choice for clinical treatment of cartilage injuries; however, fibrocartilage, not pure hyaline cartilage, has been reported because of the development of fibrosis in the repair
Hajime Utsunomiya, Xueqin Gao, Zhenhan Deng, Haizi Cheng, G. Nakama, Alex C. Scibetta, S. Ravuri, Julia L. Goldman, W. Lowe, W. Rodkey, T. Alliston, M. Philippon, J. Huard   +12 more
semanticscholar   +1 more source

Effect of Hibiscus sabdariffa and Zingiber officinale on the antihypertensive activity and pharmacokinetic of losartan in hypertensive rats

Xenobiotica; the fate of foreign compounds in biological systems, 2020
The present study aimed to determine the effect of Hibiscus sabdariffa and Zingiber officinale on antihypertensive activity and pharmacokinetic of losartan in hypertensive rats.
A. Ahad, Mohammad Raish, Y. A. Bin Jardan, M. Alam, A. Al-Mohizea, F. Al-Jenoobi   +5 more
semanticscholar   +1 more source

Losartan

Reactions Weekly, 2000
Abstract This chapter describes the evolution of the synthesis of the cardiovascular drug losartan potassium 1. This molecule, now largely in use as an antihypertensive agent, was the first approved drug of its class. The claims of the patents filed by DuPont/Merck’s researchers over the years determined the synthetic approaches that ...
Walter Cabri, Romano Di Fabio
openaire   +2 more sources

Update on Clinical Trials of Losartan With and Without β-Blockers to Block Aneurysm Growth in Patients With Marfan Syndrome: A Review.

JAMA cardiology, 2019
Importance Thoracic aortic aneurysms leading to acute aortic dissections are a major cause of morbidity and mortality despite significant advances in surgical treatment, which remains the main intervention to prevent type A dissections.
Marion A. Hofmann Bowman, K. Eagle, D. Milewicz   +2 more
semanticscholar   +1 more source