Results 121 to 130 of about 7,181,199 (327)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A simple and efficient algorithm for fused lasso signal approximator with convex loss function [PDF]

, 2010
Heng Lian
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Reading between the Lines: Using Text Analysis to Estimate the Loss Function of the ECB

, 2020
Maritta Paloviita, Markus Haavio, Pirkka Jalasjoki, Juha Kilponen, ilona vänni   +4 more
openalex   +1 more source

Sparse learning of maximum likelihood model for optimization of complex loss function [PDF]

, 2015
Ning Zhang, Prathamesh Chandrasekar
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Classification of Bone Marrow Cells Based on Dual-Channel Convolutional Block Attention Network

IEEE Access
Morphological differentiation between myeloblasts and monoblasts is pivotal for the majority of acute myeloid leukemia (AML) diagnosis in clinical settings.
Zhaorong Wang, Rui Zheng, Xiayin Zhu, Wenda Luo, Sailing He   +4 more
doaj   +1 more source

A Comparison of the Bayesian Method under Symmetric and Asymmetric Loss Functions to Estimate the Shape ParameterKof Burr Distribution

, 2018
Ida Fithriani, Arief Rachman Hakim, M Novita   +2 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

An Instance Segmentation Method for Insulator Defects Based on an Attention Mechanism and Feature Fusion Network

Applied Sciences
Among the existing insulator defect detection methods, the automatic detection of inspection robots based on the instance segmentation algorithm is relatively more efficient, but the problem of the limited accuracy of the segmentation algorithm is still ...
Junpeng Wu, Qitong Deng, Ran Xian, Xinguang Tao, Zhi Zhou   +4 more
doaj   +1 more source