Results 101 to 110 of about 10,230,762 (291)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A study on Chinese language Cross-Modal pedestrian image information retrieval [PDF]
Songklanakarin Journal of Science and Technology (SJST)This research aims to achieve cross-modal Chinese pedestrian information retrieval (CMCPIR). Most PIR tasks focus on English due to data availability, as to the best of our knowledge, there is no available Open access Chinese dataset or PIR. Therefore,
Yan Xie, Jian Qu
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A brief note on quality loss functions used in quality engineering
, 2019 In quality engineering, loss functions play a critical role in understanding process losses. Poorly operated production units and incomplete designed products cause major incidents involving monetary and social losses.
Köksoy O.
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Presbyosmia, Parkinson’s and Pharmaceutically-induced loss of olfactory function
, 2007 Olfactory function is impaired in the majority of persons with Parkinson's disease (PD). Olfactory dysfunction occurs early in the disease and is a proposed means of premorbid disease detection. However, the level of olfactory impairment is not universal
Burne, Thomas +3 more
core
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
The Macroeconomic Loss Function: A Critical Note [PDF]
The standard loss function counts both positive and negative deviations from the output and inflation targets as losses. But if the sample period is long enough, then output growth in excess of the target, and often also inflation rates that are below ...
Thomas Mayer
core +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Consequences of Tooth Loss on Oral Function and need for Replacement of Missing Teeth Among Patients Attending Muhimbili Dental Clinic [PDF]
, 2011 Tanzanian oral health services constitute mainly of tooth extractions. Consequently, individuals susceptible to dental caries and periodontal diseases will have a substantial number of missing teeth, which can affect oral function.
Quaker, Andrewleon S
core