Results 91 to 100 of about 3,028,772 (307)

Accuracy vs loss function (Red = Accuracy, Blue = Loss function).

, 2023
Accuracy vs loss function (Red = Accuracy, Blue = Loss function).
Muhammad Haris Abid (16469824), Rehan Ashraf (5047298), C. M. Nadeem Faisal (16469827), Toqeer Mahmood (4994945)   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Consequences of Tooth Loss on Oral Function and need for Replacement of Missing Teeth Among Patients Attending Muhimbili Dental Clinic [PDF]

, 2011
Tanzanian oral health services constitute mainly of tooth extractions. Consequently, individuals susceptible to dental caries and periodontal diseases will have a substantial number of missing teeth, which can affect oral function.
Quaker, Andrewleon S
core  

Advancing Pancreas Segmentation in Multi-protocol MRI Volumes using Hausdorff-Sine Loss Function [PDF]

, 2019
Computing pancreatic morphology in 3D radiological scans could provide significant insight about a medical condition. However, segmenting the pancreas in magnetic resonance imaging (MRI) remains challenging due to high inter-patient variability.
Hykoush Asaturyan, Julie Fitzpatrick, Barbara Villarini, Asaturyan, H., Thomas, E.L., Jimmy D. Bell, Villarini, B., Bell, J.D., E. Louise Thomas, Fitzpatrick, J.   +9 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

MCRCNet: A Bearing Fault Diagnosis Method for Unknown Faults Based on Transfer Learning

Applied Sciences
Bearing fault diagnosis in actual working conditions often faces the problem that unknown type faults cannot be identified, which seriously restricts the practical application of fault diagnosis technology.
Guangyuan Xu, Ruifeng Guo, Zhenyu Yin, Feiqing Zhang   +3 more
doaj   +1 more source

Biallelic loss of function variants in PPP1R21 cause a neurodevelopmental syndrome with impaired endocytic function

, 2019
Human Mutation published by Wiley Periodicals, Inc. Next-generation sequencing (NGS) has been instrumental in solving the genetic basis of rare inherited diseases, especially neurodevelopmental syndromes.
Rehman, Atteeq U, Rajab, Anna, Al-Gazali, Lihadh, Tokita, Mari J, Makrythanasis, Periklis, Hunter, Jill V, Kambouris, Marios, He, Weimin, Rad, Abolfazl, Bakey, Zeineb, Najafi, Maryam, Maroofian, Reza, Richmond, Christopher, Stark, Zornitza, et al.   +14 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Piecewise linearisation of the first order loss function for families of arbitrarily distributed random variables

, 2014
We discuss the problem of computing optimal linearisation parameters for the first order loss function of a family of arbitrarily distributed random variable.
Rossi, Roberto; id_orcid, Rossi, R., Hendrix, Eligius M.T., Hendrix, E.M.T.   +3 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source