Results 71 to 80 of about 3,028,772 (307)

The loss function of sensorimotor learning [PDF]

open access: yesProceedings of the National Academy of Sciences, 2004
Motor learning can be defined as changing performance so as to optimize some function of the task, such as accuracy. The measure of accuracy that is optimized is called a loss function and specifies how the CNS rates the relative success or cost of a particular movement outcome.
Konrad Paul, Körding, Daniel M, Wolpert
openaire   +2 more sources

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Improving the maize crop row navigation line recognition method of YOLOX

open access: yesFrontiers in Plant Science
The accurate identification of maize crop row navigation lines is crucial for the navigation of intelligent weeding machinery, yet it faces significant challenges due to lighting variations and complex environments.
Hailiang Gong, Weidong Zhuang, Xi Wang
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Colposcopic Image Segmentation Based on Feature Refinement and Attention

open access: yesIEEE Access
The current computer-aided diagnosis for cervical cancer screening encounters issues with missing detailed information during colposcopic image segmentation and incomplete edge delineation.
Yuxi He   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

DRBD-YOLOv8: A Lightweight and Efficient Anti-UAV Detection Model

open access: yesSensors
Interest in anti-UAV detection systems has increased due to growing concerns about the security and privacy issues associated with unmanned aerial vehicles (UAVs).
Panpan Jiang   +5 more
doaj   +1 more source

A Note on Forecasting the Rate of Change of the Price of Oil: Asymmetric Loss and Forecast Rationality

open access: yesEconomies, 2013
We study whether forecasts of the rate of change of the price of oil are rational. To this end, we consider a model that allows the shape of forecasters’ loss function to be studied.
Christian Pierdzioch   +1 more
doaj   +1 more source

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