Results 61 to 70 of about 10,230,762 (291)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Using Physics-Informed Neural Networks (PINNs) for Tumor Cell Growth Modeling
MathematicsThis paper presents a comprehensive investigation into the applicability and performance of two prominent growth models, namely, the Verhulst model and the Montroll model, in the context of modeling tumor cell growth dynamics.
José Alberto Rodrigues
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Developing Novel Robust Loss Functions-Based Classification Layers for DLLSTM Neural Networks
IEEE Access, 2023 In this paper, we suggest improving the performance of developed activation function-based Deep Learning Long Short-Term Memory (DLLSTM) structures by employing robust loss functions like Mean Absolute Error $(MAE)$ and Sum Squared Error $(SSE)$ to ...
Mohamad Abou Houran +5 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Piecewise linearisation of the first order loss function for families of arbitrarily distributed random variables [PDF]
, 2014 We discuss the problem of computing optimal linearisation parameters for the first order loss function of a family of arbitrarily distributed random variable.
Rossi, Roberto; id_orcid +3 more
core
Estimation of the slope parameter in a linear regression model under a bounded loss function
, 2023 The estimation of the slope parameter of a simple linear regression model in the presence of nonsample prior information under the reflected normal loss function is considered.
M. Naghizadeh Qomi +5 more
core +1 more source