Results 161 to 170 of about 1,547,225 (303)
A note on the stop-loss preservin property of Wang's premium principle. [PDF]
A desirable property for a premium principle is that it preserves stop-loss order. In this paper, we present a simple proof for the stop-loss preserving property of Wang's class of premium principles, in the case that the distribution functions involved ...
Goovaerts, Marc, Ribas, C, Dhaene, Jan
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
DeepFold: enhancing protein structure prediction through optimized loss functions, improved template features, and re-optimized energy function. [PDF]
Bioinformatics, 2023 Lee JW +18 more
europepmc +1 more source
Operational loss modelling for process facilities using multivariate loss functions
, 2015 This paper presents a methodology to develop multivariate loss functions to measure the operational loss of process facilities. The proposed methodology uses loss functions to provide a model for operational loss due to deviation of key process ...
Ahmed, S (15557018) +2 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Impact of loss functions on the performance of a deep neural network designed to restore low-dose digital mammography. [PDF]
Artif Intell Med, 2023 Shan H +4 more
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Perceptually motivated loss functions for computer generated holographic displays. [PDF]
Sci Rep, 2022 Yang F +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source