Results 91 to 100 of about 2,094,825 (313)

Variational Characterizations of Local Entropy and Heat Regularization in Deep Learning

open access: yes, 2019
The aim of this paper is to provide new theoretical and computational understanding on two loss regularizations employed in deep learning, known as local entropy and heat regularization.
Kaplan, Zach   +2 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Quantum Coherence and Closed Timelike Curves

open access: yes, 1995
Various calculations of the $S$ matrix have shown that it seems to be non unitary for interacting fields when there are closed timelike curves. It is argued that this is because there is loss of quantum coherence caused by the fact that part of the ...
A. Anderson   +13 more
core   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

APPLICATION OF DIMENSIONAL ANALYSIS IN HEAT LOSS DETERMINING IN DISTRICT HEATING SYSTEMS

open access: yesActa Polytechnica, 2016
Existing procedures for determining the heat loss in heat distribution use balance relations, or rather they are based on the theory of heat and mass transfer.
Mária Čarnogurská   +2 more
doaj   +1 more source

Thermionic triode generates ac power [PDF]

open access: yes, 1970
Electrostatic grid controls conduction cycle of thermionic diode to convert low dc output voltages to high ac power without undesirable power loss. An ac voltage applied to the grid of this new thermionic triode enables it to convert heat directly into ...
Kniazzeh, A. G. F., Scharz, F. C.
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Heat Loss Calculation of the Electric Drives

open access: yesMachines
In the realm of sustainable public transportation, the integration of intelligent electric bus propulsion systems represents a novel and promising approach to reducing environmental impact—particularly through the mitigation of NOx emissions and overall ...
Tamás Sándor   +3 more
doaj   +1 more source

Experimental study of flow distribution with circumferential manifolds [PDF]

open access: yes, 1972
Water flow test results on fluid flow distribution and pressure loss in curved manifolds with tangential or radial entry are reported. Manifolds were studied both as inlet and outlet manifolds. Manifolds can be used for boilers and/or heat exchangers for
Dittrich, R. T.
core   +1 more source

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