Results 101 to 110 of about 2,094,825 (313)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Indoor thermal performance evaluation of Daystar solar collector [PDF]

open access: yes
The test procedures used and results obtained from a test program to obtain thermal performance data on a Daystar Model 21B, S/N 02210, Unit 2, liquid solar collector under simulated conditions are described.
Shih, K., Sr.
core   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu   +10 more
wiley   +1 more source

Efficiency stud

open access: yesAlexandria Engineering Journal, 2016
This paper presents the study of combination tube boilers, as applicable to commercial use, along with the significant features, limitations, and applicability.
Brundaban Patro
doaj   +1 more source

Smooth bumps, a Borel theorem and partitions of smooth functions on p.c.f. fractals

open access: yes, 2009
We provide two methods for constructing smooth bump functions and for smoothly cutting off smooth functions on fractals, one using a probabilistic approach and sub-Gaussian estimates for the heat operator, and the other using the analytic theory for p.c ...
Rogers, Luke G   +2 more
core   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati   +10 more
wiley   +1 more source

Unveiling the link between occupational heat strain and productivity loss: evidence from South Indian informal sectors

open access: yesDiscover Public Health
Introduction In an economy like India where the informal sector dominates, occupational heat stress poses significant challenges to worker productivity.
Vidhya Venugopal   +5 more
doaj   +1 more source

NECAP 4.1: NASA's Energy Cost Analysis Program thermal response factor routine [PDF]

open access: yes
A thermal response factor is described and calculation sequences and flowcharts for RESFAC2 are provided. RESFAC is used by NASA's (NECAP) to calculate hourly heat transfer coefficients (thermal response factors) for each unique delayed surface.
Weise, M. R.
core   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz   +3 more
wiley   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar   +3 more
wiley   +1 more source

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