Results 71 to 80 of about 389,923 (287)

Bayes risk minimization using metric loss functions [PDF]

Interspeech 2005, 2005
In this work, fundamental properties of Bayes decision rule us- ing general loss functions are derived analytically and are ver- ified experimentally for automatic speech recognition. It is shown that, for maximum posterior probabilities larger than 1/2, Bayes decision rule with a metric loss function always decides on the posterior maximizing class ...
Schlüter, Ralf, Scharrenbach, Thomas, Steinbiss, Volker, Ney, Hermann   +3 more
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Fast rates for noisy clustering [PDF]

, 2012
The effect of errors in variables in empirical minimization is investigated. Given a loss $l$ and a set of decision rules $\mathcal{G}$, we prove a general upper bound for an empirical minimization based on a deconvolution kernel and a noisy sample $Z_i ...
Pack Kaelbling, Sébastien Loustau
core   +3 more sources

Complexity regularization via localized random penalties

, 2003
In this article, model selection via penalized empirical loss minimization in nonparametric classification problems is studied. Data-dependent penalties are constructed, which are based on estimates of the complexity of a small subclass of each model ...
Lugosi, Gabor, Wegkamp, Marten
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Experimental Identification of the Optimal Current Vectors for a Permanent-Magnet Synchronous Machine in Wave Energy Converters

Energies, 2019
This paper investigates efficiency enhancements in Permanent-Magnet Synchronous Machines (PMSMs) used as generators in wave energy converters. A method is presented, which allows experimental identification of the optimal current vectors leading to ...
Simon Krüner, Christoph M. Hackl
doaj   +1 more source

A new fuzzy support vector machine with pinball loss

Discover Artificial Intelligence, 2023
The fuzzy support vector machine (FSVM) assigns each sample a fuzzy membership value based on its relevance, making it less sensitive to noise or outliers in the data.
Ram Nayan Verma, Rahul Deo, Rakesh Srivastava, Naidu Subbarao, Gajendra Pratap Singh   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A Survey of Machine Learning Techniques for Optimal Capacitor Placement and Sizing in Smart Distribution Networks

IEEE Access
The increasing complexity of modern power distribution networks necessitates advanced strategies for reactive power compensation, particularly in capacitor placement and sizing.
Kwabena Addo, Katleho Moloi, Musasa Kabeya, Evans Eshiemogie Ojo   +3 more
doaj   +1 more source