Results 41 to 50 of about 4,286 (261)

Evaluating direct vessel injection accident-event progression of AP1000 and key figures of merit to support the design and development of water-cooled small modular reactors

Nuclear Engineering and Technology
The passive safety systems (PSSs) within water-cooled reactors are meticulously engineered to function autonomously, requiring no external power source or manual intervention.
Hossam H. Abdellatif, Palash K. Bhowmik, David Arcilesi, Piyush Sabharwall   +3 more
doaj   +1 more source

Simulation of VVER-1000 Guillotine Large Break Loss of Coolant Accident Using RELAP5/SCDAPSIM/MOD3.5

Journal of Nuclear Engineering, 2021
The safety performance of nuclear power plants (NPPs) is a very important factor in evaluating nuclear energy sustainability. Safety analysis of passive and active safety systems have a positive influence on reactor transient mitigation.
Fabiano Gibson Daud Thulu, Ayah Elshahat, Mohamed H. M. Hassan   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Simulation of loss-of-coolant accident with thin-walled cladding tubes

Nuclear Materials and Energy
A loss-of-coolant accident in a nuclear power plant was simulated in the CODEX-SLIM experiment. The electrically heated fuel rod bundle contained cladding material used at a VVER-440 power plant.
Róbert Farkas, Zoltán Hózer, Zoltán Kis, Erzsébet Perez-Feró, Márton Király, Márta Horváth, Tamás Novotny, Péter Szabó, Tamás Bubonyi   +8 more
doaj   +1 more source

Fuel melting time following a loss of coolant [PDF]

, 1966
A knowledge of the fuel temperature transient following a reactor flow-loss accident is important in reactor confinement studies, since the rate an time of fission product release depend upon this transient. Fuel melting times presented by Ekern, Muraoka, and Zaloudek have been used in past confinement studies.
openaire   +2 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Reactor behavior comparisons for two liquid metal-cooled fast reactors during an event of loss of coolant

Case Studies in Thermal Engineering, 2019
The aim of this paper is to present a fast-numerical tool based on the average channel approach to analyze the response of fast reactors under unprotected loss of flow events.
Alejandría-D. Pérez-Valseca, Sergio Quezada-García, Armando-M. Gómez-Torres, Alejandro Vázquez-Rodríguez, Gilberto Espinosa-Paredes   +4 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source