Results 181 to 190 of about 138,753 (343)

How clonal are clones? A quest for loss of heterozygosity during asexual reproduction in Daphnia magna [PDF]

, 2019
Marinela Dukić, Daniel Berner, Christoph R. Haag, Dieter Ebert   +3 more
openalex   +1 more source

Soft selection reduces loss of heterozygosity in asexual reproduction [PDF]

, 2023
Marco Archetti
openalex   +1 more source

Loss of heterozygosity in pseudoexfoliation syndrome.

Investigative ophthalmology & visual science, 1999
Pseudoexfoliation (PEX) syndrome is characterized by the accumulation of a material of unknown origin in the anterior structures of the eye. Loss of heterozygosity (LOH) in a genetic locus indicates the presence of a gene located in the same region that could be implicated in the development or the progression of a disease.
V P, Kozobolis, E T, Detorakis, G, Sourvinos, I G, Pallikaris, D A, Spandidos   +4 more
openaire   +1 more source

Cidea Targeting Protects Cochlear Hair Cells and Hearing Function From Drug‐ and Noise‐Induced Damage

Advanced Science, EarlyView.
Acquired sensorineural hearing loss is primarily caused by the damage or loss of cochlear hair cells, induced by factors such as noise exposure and ototoxic drugs. The deficiency of apoptosis‐inducing gene Cidea in Cidea KO mice or by delivering CRISPR/SlugCas9‐HF via AAV to edit Cidea effectively alleviated hair cell damage and hearing loss caused by ...
Shasha Zhang, Ruiying Qiang, Yuan Zhang, Jinxian Wan, Chen Tao, Ying Dong, Xujun Tang, Li Xu, Hairong Xiao, Yanqin Lin, Wei Tong, Ying Ma, Yongming Wang, Peng Li, Renjie Chai   +14 more
wiley   +1 more source

Polyploidy as an Adaptation against Loss of Heterozygosity in Cancer. [PDF]

Int J Mol Sci, 2022
Archetti M.
europepmc   +1 more source

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

Advanced Science, EarlyView.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai, Tongtong Li, Qian Fang, Ziyou Bao, Feng Kong, Huitao Qi, Hanzhen Li, Mingyu Zhang, Wei Wang, Yongxia Guan, Wenbo Liu, Xiangfeng Chen, Zi‐Jiang Chen, Xiaohua Jiang, Xin Wang, Hongbin Liu   +15 more
wiley   +1 more source

Gain and Loss of Heterozygosity in the Genome of the Asexual Nematode Halicephalobus mephisto. [PDF]

J Mol Evol
Amini A, Bracht JR.
europepmc   +1 more source

Loss of heterozygosity does not occur in BRCA1/2 mutant pediatric solid and central nervous system tumors. [PDF]

Pediatr Blood Cancer, 2023
Groves A, Ward A, Li YY, Lazo de la Vega L, Nag A, Forrest SJ, Gupta HV, Thorner AR, Meyerson M, Kamihara J, Cherniack AD, Janeway KA.   +11 more
europepmc   +1 more source

The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers.

, 1995
Hermann Aberle, Christiane Bierkamp, Delphine Torchard, O Serova, Thomas Wagner, E. Natt, Johann Wirsching, C Heidkämper, Marco Montagna, Henry T. Lynch   +9 more
openalex   +2 more sources

Somatic mosaicism for copy-neutral loss of heterozygosity and DNA copy number variations in the human genome [PDF]

, 2015
Olga Žilina, Marina Koltšina, Raivo Raid, Ants Kurg, Neeme Tõnisson, Andres Salumets   +5 more
openalex   +1 more source