Results 251 to 260 of about 173,415,106 (290)

Loss of heterozygosity of the PTCH gene in ameloblastoma

Human Pathology, 2012
Ameloblastoma is a locally aggressive benign neoplasm derived from odontogenic epithelium, with high recurrence rates. Alterations in the Sonic Hedgehog signaling pathway, including PTCH gene mutations, have been associated with the pathogenesis of some odontogenic tumors.
Lucyana Conceição, Farias, Carolina Cavalieri, Gomes, João Artur Ricieri, Brito, Clarice Ferreira, Galvão, Marina Gonçalves, Diniz, Wagner Henriques, de Castro, Vanessa de Fátima, Bernardes, Luiz Armando, De Marco, Ricardo Santiago, Gomez   +8 more
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LOSS OF HETEROZYGOSITY - ORIGIN OR RESULT OF CARCINOGENESIS

International Journal of Oncology, 1993
Loss of heterozygosity has recently been discussed in the field of carcinogenesis, since loss of tumor suppressor gene has been believed to play a key role in carcinogenesis. However, recent evidence suggests that the loss of heterozygosity is a non-specific process in tumor progression rather than a specific process of carcinogenesis.
M, Chigira, S, Arita, H, Watanabe
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Loss of heterozygosity in human skin

Journal of the American Academy of Dermatology, 1999
Loss of heterozygosity (LOH) is a genetic mechanism by which a heterozygous somatic cell becomes either homozygous or hemizygous because the corresponding wild-type allele is lost. LOH has today been recognized as a major cause of malignant growth. This article gives a comprehensive review of skin disorders in which an origin from LOH has been either ...
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Loss of heterozygosity and p53 expression in Pterygium

Cancer Letters, 2004
While the pathogenesis of pterygium is still not well understood, environmental factors such at UV light, appear to play an important role in its development. UV radiation can cause mutations in genes such as the p53 tumor suppressor gene, that when inactivated through mutation and loss of heterozygosity can lead to cell proliferation and genomic ...
David, Reisman, Jennifer Wallace, McFadden, Gary, Lu   +2 more
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Loss of Heterozygosity in Bilateral Breast Cancer

Breast Cancer Research and Treatment, 2000
Women who develop bilateral breast cancer at an early age are likely to harbour germline mutations in breast cancer susceptibility genes. The aim of this study was to test for concordant genetic changes in left and right breast cancer of young women (age < 50) with bilateral breast cancer that may suggest an inherited breast cancer predisposition ...
J, Kollias, S, Man, M, Marafie, K, Carpenter, S, Pinder, I O, Ellis, R W, Blamey, G, Cross, J D, Brook   +8 more
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Loss of constitutional heterozygosity in human astrocytomas

Acta Neurochirurgica, 1992
Inactivation of tumour suppressor genes or anti-oncogenes as well as activation of dominant acting oncogenes seem to be important mechanisms in the pathogenesis of gliomas. We compared constitutional and tumoural genotypes at different restriction fragment length polymorphism loci (RFLP) on chromosomes 10 and 17 in 15 unrelated individuals.
van de Kelft, E., de Boulle, K., Willems, P., Martin, J.-J., Selosse, P., van der Auwera, B.   +5 more
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Loss of heterozygosity in human germinal tumors

Cytogenetics and Cell Genetics, 2008
The frequency of losses of heterozygosity has been investigated in 14 germinal tumors of the testis. Nonrandom deletion of whole or part of chromosome 11 was observed in four cases. In addition, loss of heterozygosity of all the informative loci analyzed was detected in one ovarian teratoma, indicating its post-meiotic origin.
P, Radice, M A, Pierotti, S, Lacerenza, P, Mondini, M T, Radice, S, Pilotti, G, Della Porta   +6 more
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Loss of Heterozygosity of 14q32 in Colorectal Carcinoma

Cancer Genetics and Cytogenetics, 1999
Previous allelotyping studies on colorectal carcinoma suggest that loss of heterozygosity (LOH) on chromosome 14q may be a common genetic alteration in this tumor type. The purpose of this study was to determine precise frequency of LOH at 14q32 region in colorectal carcinomas and to define a minimal region of LOH. LOH at 14q32 in 66 primary colorectal
T, Bando, Y, Kato, Y, Ihara, F, Yamagishi, K, Tsukada, M, Isobe   +5 more
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LOHAS: loss‐of‐heterozygosity analysis suite

Genetic Epidemiology, 2011
AbstractDetection of loss of heterozygosity (LOH) plays an important role in genetic, genomic and cancer research. We develop computational methods to estimate the proportion of homozygous SNP calls, identify samples with structural alterations and/or unusual genotypic patterns, cluster samples with close LOH structures and map the genomic segments ...
Hsin-Chou, Yang, Lun-Ching, Chang, Richard M, Huggins, Chun-Houh, Chen, Charles G, Mullighan   +4 more
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Analysis of Loss of Heterozygosity in Circulating DNA

2009
Analysis of genetic altera tion in circulating DNA can have clinical utility in predicting disease outcome. Loss of heterozygosity (LOH) of DNA microsatellites has been shown to occur commonly among all chromosomes in various cancers, such as melanoma, breast cancer, and lung cancer.
Takeshi, Nakamura, Eiji, Sunami, Tuny, Nguyen, Dave S B, Hoon   +3 more
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