Results 301 to 310 of about 137,449 (345)

Loss of Heterozygosity

2009
The most common molecular alteration observed in human cancers,1 loss of heterozygosity (LOH), is a significant mecha-nism by which critical genes involved in growth regulation and homeostasis become inactivated, or silenced, during disease evolution. This chapter provides a review of LOH and its implications in various cancers as well as a review of ...
Belinda J. Wagner, Sharon C. Presnell
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Loss of heterozygosity by SCRaMbLEing

Science China Life Sciences, 2019
Genetic variation drives phenotypic evolution within populations. Genetic variation can be divided into different forms according to the size of genomic changes. However, study of large-scale genomic variation such as structural variation and aneuploidy is still limited and mainly based on the static, predetermined feature of individual genomes.
Yunxiang, Li, Yi, Wu, Lu, Ma, Zhou, Guo, Wenhai, Xiao, Yingjin, Yuan   +5 more
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LOHAS: loss‐of‐heterozygosity analysis suite

Genetic Epidemiology, 2011
AbstractDetection of loss of heterozygosity (LOH) plays an important role in genetic, genomic and cancer research. We develop computational methods to estimate the proportion of homozygous SNP calls, identify samples with structural alterations and/or unusual genotypic patterns, cluster samples with close LOH structures and map the genomic segments ...
Hsin-Chou, Yang, Lun-Ching, Chang, Richard M, Huggins, Chun-Houh, Chen, Charles G, Mullighan   +4 more
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Loss of Heterozygosity in Endometrial Carcinoma

International Journal of Gynecological Pathology, 2008
Inactivation of a tumor suppressor gene typically occurs in two steps, thus fulfilling Knudson hypothesis. One "hit" is frequently a point mutation or a small deletion. The other alteration is usually a large genomic loss of part of a gene, or even part of a chromosome, or the whole chromosome.
Ana, Velasco, Judit, Pallares, Maria, Santacana, Andre, Yeramian, Xavier, Dolcet, Nuria, Eritja, Soraya, Puente, Anabel, Sorolla, Nuria, Llecha, Xavier, Matias-Guiu   +9 more
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Loss of heterozygosity in liver tumours

Journal of Hepatology, 1995
ARCINOGENESIS is a multifactorial and multistep C process. In the process genetic factors play a pivotal role. There is a wealth of evidence that cancer is a set of fundamentally genetic diseases (1,2). While about 1% of total cancer patients inherit their tumours (3), genetic abnormalities have been demonstrated in all types of cancers, either ...
S F, Ding, N A, Habib
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Mechanisms of loss of heterozygosity in retinoblastoma

Cytogenetic and Genome Research, 1992
Retinoblastoma (RB) tumors arise when both alleles of the RBI gene are inactivated by two mutational events (Ml and M2). Ml can be an initial germline or somatic mutation; M2 is frequently loss of heterozygosity (LOH), which makes the cell homozygous or hemizygous for the original mutation. LOH is the major mechanism by which many cancers are initiated.
X, Zhu, J M, Dunn, A D, Goddard, J A, Squire, A, Becker, R A, Phillips, B L, Gallie   +6 more
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Loss of heterozygosity in Neuroblastomas—an Overview

European Journal of Cancer, 1997
Although previous studies have demonstrated a relatively high incidence of loss of heterozygosity (LOH) on chromosomes 1p, 11q and 14q in neuroblastoma, it is unclear whether LOH occurs specifically on these chromosomes or not. It might be due to the lack of allelotyping of neuroblastoma. When we assessed all 22 autosomes and chromosome X for LOH in 81
J, Takita, Y, Hayashi, J, Yokota
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Loss of heterozygosity in human skin

Journal of the American Academy of Dermatology, 1999
Loss of heterozygosity (LOH) is a genetic mechanism by which a heterozygous somatic cell becomes either homozygous or hemizygous because the corresponding wild-type allele is lost. LOH has today been recognized as a major cause of malignant growth. This article gives a comprehensive review of skin disorders in which an origin from LOH has been either ...
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Loss of heterozygosity analysis in malignant gliomas

Brain Tumor Pathology, 2011
Despite recent advances in the diagnosis and treatment of glioblastomas, patient outcomes for these highly malignant tumors remain poor. Research into the molecular pathology of glioblastoma has uncovered various genetic changes that contribute to malignancy.
Masahiro, Mizoguchi, Daisuke, Kuga, Yanlei, Guan, Nobuhiro, Hata, Akira, Nakamizo, Koji, Yoshimoto, Tomio, Sasaki   +6 more
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Loss of heterozygosity in human germinal tumors

Cytogenetic and Genome Research, 1989
The frequency of losses of heterozygosity has been investigated in 14 germinal tumors of the testis. Nonrandom deletion of whole or part of chromosome 11 was observed in four cases. In addition, loss of heterozygosity of all the informative loci analyzed was detected in one ovarian teratoma, indicating its post-meiotic origin.
P, Radice, M A, Pierotti, S, Lacerenza, P, Mondini, M T, Radice, S, Pilotti, G, Della Porta   +6 more
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