Results 311 to 320 of about 137,449 (345)

Loss of Heterozygosity in Bilateral Breast Cancer

Breast Cancer Research and Treatment, 2000
Women who develop bilateral breast cancer at an early age are likely to harbour germline mutations in breast cancer susceptibility genes. The aim of this study was to test for concordant genetic changes in left and right breast cancer of young women (age < 50) with bilateral breast cancer that may suggest an inherited breast cancer predisposition ...
J, Kollias, S, Man, M, Marafie, K, Carpenter, S, Pinder, I O, Ellis, R W, Blamey, G, Cross, J D, Brook   +8 more
openaire   +2 more sources

Loss of constitutional heterozygosity in human astrocytomas

Acta Neurochirurgica, 1992
Inactivation of tumour suppressor genes or anti-oncogenes as well as activation of dominant acting oncogenes seem to be important mechanisms in the pathogenesis of gliomas. We compared constitutional and tumoural genotypes at different restriction fragment length polymorphism loci (RFLP) on chromosomes 10 and 17 in 15 unrelated individuals.
van de Kelft, Erik, de Boulle, K., Willems, P., Martin, Jean-Jacques, Selosse, Paul, van der Auwera, B.   +5 more
openaire   +3 more sources

Loss of heterozygosity and the origin of meningioma

Human Genetics, 1987
In some human tumors, loss of particular genes manifested indirectly by loss of heterozygosity for specific RFLPs seems to uncover either heterozygous deletions leading to a gene doses effect or homozygous deletions due to a silent allele at the corresponding locus, both causing the loss of regulatory functions (antioncogenes, suppressor genes ...
E, Meese, N, Blin, K D, Zang
openaire   +2 more sources

LOSS OF HETEROZYGOSITY - ORIGIN OR RESULT OF CARCINOGENESIS

International Journal of Oncology, 1993
Loss of heterozygosity has recently been discussed in the field of carcinogenesis, since loss of tumor suppressor gene has been believed to play a key role in carcinogenesis. However, recent evidence suggests that the loss of heterozygosity is a non-specific process in tumor progression rather than a specific process of carcinogenesis.
M, Chigira, S, Arita, H, Watanabe
openaire   +2 more sources

Loss of Heterozygosity of 14q32 in Colorectal Carcinoma

Cancer Genetics and Cytogenetics, 1999
Previous allelotyping studies on colorectal carcinoma suggest that loss of heterozygosity (LOH) on chromosome 14q may be a common genetic alteration in this tumor type. The purpose of this study was to determine precise frequency of LOH at 14q32 region in colorectal carcinomas and to define a minimal region of LOH. LOH at 14q32 in 66 primary colorectal
T, Bando, Y, Kato, Y, Ihara, F, Yamagishi, K, Tsukada, M, Isobe   +5 more
openaire   +2 more sources

Analysis of Loss of Heterozygosity in Circulating DNA

2009
Analysis of genetic altera tion in circulating DNA can have clinical utility in predicting disease outcome. Loss of heterozygosity (LOH) of DNA microsatellites has been shown to occur commonly among all chromosomes in various cancers, such as melanoma, breast cancer, and lung cancer.
Takeshi, Nakamura, Eiji, Sunami, Tuny, Nguyen, Dave S B, Hoon   +3 more
openaire   +2 more sources

Loss of Heterozygosity

2013
Steven J. Frampton, Emma V. King
openaire   +2 more sources

Loss of heterozygosity in laryngeal cancer.

Roczniki Akademii Medycznej w Bialymstoku (1995), 2005
Head and neck cancers account for about 6% of all human cancers. Molecular changes leading to the disease development and progression still remain not fully explained. Examination of loss of heterozygosity (allelic loss, LOH) using the specific microsatellite markers is a method of choice in assessing tumour suppressor genes (TSGs) localisation in ...
M, Rogowski, I, Walenczak, W, Pepiński, M, Skawrońska, A, Sieśkiewicz, J, Klatka   +5 more
openaire   +1 more source

Loss of heterozygosity in tertiary hyperparathyroidism

Transplantation Proceedings, 2002
E, Konya, H, Tsuji, N, Amasaki, T, Umekawa, M, Iguchi, T, Kurita   +5 more
openaire   +2 more sources

Loss of Heterozygosity

2011
openaire   +2 more sources