Results 31 to 40 of about 4,964,718 (249)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Urban Area Propagation Path Loss Reduction by Dynamic Differential Evolution Algorithm [PDF]

[[abstract]]In the wireless outdoor communication, the buildings in modern cities to make the outdoor communication more difficult. In this paper, we propose the shooting and bouncing ray/image (SBR/Image) method to compute the path loss for outdoor ...
Wu, C. Y.
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Topological analysis of the power grid and mitigation strategies against cascading failures [PDF]

, 2010
This paper presents a complex systems overview of a power grid network. In recent years, concerns about the robustness of the power grid have grown because of several cascading outages in different parts of the world.
Hodges, Amelia, Pahwa, Sakshi, Scoglio, Caterina, Wood, Sean   +3 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Loss reduction in cable sheathing

RE&PQJ
In order to reduce electric potential difference between the sheathings of single core three-phase cables, the sheathing is grounded and bonded at one or both ends of the cables. If the cable is long, double bonding has to be carried out which leads to circulating currents and increased power loss.
null B. Novák, null L. Koller, null I. Berta   +2 more
openaire   +1 more source

Conditional Density Estimation with Dimensionality Reduction via Squared-Loss Conditional Entropy Minimization [PDF]

, 2014
Regression aims at estimating the conditional mean of output given input. However, regression is not informative enough if the conditional density is multimodal, heteroscedastic, and asymmetric.
Sugiyama, Masashi, Tangkaratt, Voot, Xie, Ning   +2 more
core   +1 more source

Energy loss of ions by electric-field fluctuations in a magnetized plasma

, 2011
The results of a theoretical investigation of the energy loss of charged particles in a magnetized classical plasma due to the electric field fluctuations are reported. The energy loss for a test particle is calculated through the linear-response theory.
Deutsch, Claude, Nersisyan, Hrachya B.
core   +1 more source