Results 91 to 100 of about 103,300,016 (308)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Incidence and predictors of loss to follow-up among HIV infected adults after initiation of first line anti-retroviral therapy at University of Gondar comprehensive specialized Hospital Northwest Ethiopia, 2018: retrospective follow up study

BMC Research Notes, 2019
Objectives The aim of this study was to estimate the incidence of lost to follow up from anti-retroviral therapy (ART) care and identify the associated factors among human immunodeficiency virus (HIV) infected patients after first-line ART initiation at ...
Nebiyu Mekonnen, Mohamed Abdulkadir, Eleyias Shumetie, Adhanom Gebreegziabher Baraki, Melaku Kindie Yenit   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Drug-resistant TB in Morobe Province, Papua New Guinea, 2012–2021

Public Health Action
SETTING: Papua New Guinea (PNG) is a high-burden country for multidrug-resistant or rifampicin-resistant TB (MDR/RR-TB). There are limited data on MDR/RR-TB notifications and treatment from the most populous province.
L. Bumbu, S. Vaccher, A. Holmes, K. Sodeng, S.M. Graham, Y.D. Lin   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Sense of coherence and attrition during four-year follow-up in cohorts of permanent and non-permanent Finnish employees [PDF]

, 2008
Background We studied whether health resources, measured as sense of coherence (SOC), are associated with participation in a follow-up survey among permanent and non-permanent employees who responded at baseline.
Vahtera, Jussi, Kivimäki, Mika, Liukkonen, Virpi, Pentti, Jaana, Mika Kivimäki, Pentti, J, Vahtera, J, Kivimäki Mika, Pentti Jaana, Virtanen, Pekka, Jaana Pentti, Kivimaki, M, Vahtera Jussi, Jussi Vahtera, Virpi Liukkonen, Liukkonen Virpi, Virtanen, P, Virtanen Pekka, Pekka Virtanen, Liukkonen, V   +19 more
core   +2 more sources

Loss to follow up within an HIV cohort

Journal of the International AIDS Society, 2012
BHIVA guidelines recommend that all ARV‐naïve and stable on‐treatment patients are monitored at least 6 monthly [1]. Studies have shown that loss to follow up (LFU) not only worsens outcomes [2] but has increased potential for onward transmission. Case notes of 1275 HIV patients registered under our care up to January 2011 were examined for attendance ...
Wood, H., Dhar, J.
openaire   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Predictors of loss to follow-up in antiretroviral treatment for adult patients in the Oromia region, Ethiopia

, 2016
Abebe Megerso,1 Sileshi Garoma,1 Tolosa Eticha,2 Tilaye Workineh,1 Shallo Daba,3 Mihretu Tarekegn,3 Zelalem Habtamu31Department of Public Health, Adama Hospital Medical College,2Department of Pediatrics and Child Health, Adama Hospital Medical College ...
Workineh T, Daba S, Eticha T, Tarekegn M, Habtamu Z, Garoma S, Megerso A   +6 more
core