Results 141 to 150 of about 103,300,016 (308)

Time under observation until loss to follow-up or withdrawal.

, 2014
Time under observation until loss to follow-up or withdrawal.
Marcus Y. Chen (298448), Matthew Law (36008), Sandra M. Walker (663733), Jane S. Hocking (173696), Catriona S. Bradshaw (169624), Christopher K. Fairley (169632), Clare Bellhouse (457503), Jade E. Bilardi (457499), Katherine A. Fethers (663734), Lenka A. Vodstrcil (173720), Dana S. Forcey (515123), Susan Petersen (663735)   +11 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Evaluation of treatment outcomes and associated risk factors in children with TB in Bangladesh

Public Health Action
BACKGROUND: Children aged 0–14 years old make up 4% of the total number of people diagnosed with TB in Bangladesh. Local pediatric treatment outcomes and associated factors are poorly understood; further understanding can inform tailored interventions to
A. Madan, S. Kulkarni, M.M. Rahman, F. Hossain, M.K. Kamul, J.I. Campbell, M.T. Rahman, J. Creswell, H. Hussain, T. Roy, A.A. Malik, M.B. Brooks   +11 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Long-term results of a hydroxyapatite-coated femoral component in total hip replacement. A 15- to 21-year follow up study

, 2007
Between 1986 and 1991 we implanted 331 consecutive Furlong hydroxyapatite-coated femoral components of a total hip replacement in 291 patients. A cemented acetabular prosthesis was used in 217 hips and a hydroxyapatite-coated component in 114.
Rajaratnam, S.S., A. Tavakkolizadeh, R J Fletcher (13437510), Jack, C., George, M.D., A Tavakkolizadeh (16046336), Fletcher, R.J., S. S. Rajaratnam, C Jack (16046333), J. A. N. Shepperd, J A N Shepperd (16046342), Sheppard, J.A.N., C. Jack, Tavakkolizadeh, A., Hankins, M., M. Hankins, R. J. Fletcher, M Hankins (50557), M. D. George, S S Rajaratnam (16046330), M D George (16046339)   +20 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

HIV prevalence and determinants of loss-to-follow-up in adolescents and young adults with tuberculosis in Cape Town

, 2019
TB remains a leading cause of mortality and morbidity in sub-Saharan Africa, due to the HIV epidemic. As TB treatment is lengthy, the completion of the full course of treatment may be especially challenging for young people.
Pancho Mulongeni (705454), Sabine Hermans (741528), Judy Caldwell (342298), Robin Wood (4924), Richard Kaplan (282414), Linda-Gail Bekker (60754), Pancho Mulongeni, Linda-Gail Bekker, Robin Wood, Richard Kaplan, Sabine Hermans, Judy Caldwell   +11 more
core   +1 more source

Adherence to the follow-up of the newborn exposed to syphilis and factors associated with loss to follow-up.

Revista brasileira de epidemiologia = Brazilian journal of epidemiology, 2018
All newborns exposed to syphilis in pregnancy must have outpatient follow-up. The interruption of this follow-up especially threatens those children who were not treated at birth.To describe the clinical, epidemiological, and sociodemographic characteristics of pregnant women with syphilis and their newborns, and to investigate the factors associated ...
Marjorie Cristiane, Feliz, Adeli Regina Prizybicien, de Medeiros, Andrea Maciel, Rossoni, Tony, Tahnus, Adriane Miro Vianna Benke, Pereira, Cristina, Rodrigues   +5 more
openaire   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source