Results 171 to 180 of about 103,300,016 (308)

Understanding Drivers of Loss to Follow-Up in HIV Care in Oromia Regional State, Ethiopia: A Qualitative Grounded Theory. [PDF]

Health Sci Rep
Tafese F, Gezahegn M, Kura Z, Alemayehu E, Ayana Y, Bafikadu C, Belako G, Zerfu T, Sori BK, Dassie Y, Bekele F, Sime N, Degfie TT, Yilma D, Ejigu Y, Kebede Y, Woldie M.   +16 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Loss to Follow-Up and Visit Nonadherence in an HIV Incidence Cohort in Kisumu, Kenya. [PDF]

J Acquir Immune Defic Syndr
Serti E, Bartolanzo D, Frndak S, Owuoth J, Yates A, Hamby T, Nwoga C, Otieno J, Smith HJ, Schluck G, Polyak CS, Sing'oei V, Crowell TA, RV393 Study team.   +13 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Factors associated with loss to follow-up after point-of-care diabetic retinopathy examination in a teleophthalmology program: A retrospective cohort study. [PDF]

PLoS One
Bonilla-Escobar FJ, Atta S, Eibel MR, Wesalo JS, Chang JT, Sánchez-Cano D, Eller A, Waxman EL.   +7 more
europepmc   +1 more source

Milky ascites after loss to follow-up: Figure 1

BMJ Case Reports, 2009
Rakesh, Biswas, Omar, Irfan, Jyoti, Valecha, Virendra, Chowdhury, Sanjay, Tandon   +4 more
openaire   +3 more sources

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

The association of rural residence with aneurysm presentation and loss to follow-up after endovascular aneurysm repair in the Vascular Quality Initiative. [PDF]

J Vasc Surg
Inkollu S, Hussain A, Beidelman E, Rothenberg P, Kalbaugh C, Minc SD.   +5 more
europepmc   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source