Results 61 to 70 of about 522,669 (248)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
A Lossy Compression Tolerant Data Hiding Method Based on JPEG and VQ
, 2010 A lossy compression tolerant data hiding method is proposed in this paper. The image which hides data is named a stego-image. Most of data hiding methods will lose some hidden data when the stego-image is compressed by iossy compression process. However,
黃仁俊; Hwang, Ren-junn; 施國琛; Shih, Timothy K.; Kao, Chuan-ho
core +1 more source
Review of Very Low Bitrate Image Compression Techniques
Shuju Caiji Yu ChuliImage is one of the important ways to obtain information. With the increasing demand of image transmission and storage， especially in bandwidth limited or cloud storage situations， compressing images at extremely low bitrates is of great significance for
YUE Shuang, CHEN Zhe, YIN Fuliang
doaj +1 more source
HYBRID COMPRESSION OF CERVICAL IMAGES BY SEGMENTING NUCLEI-CYTOPLASM [PDF]
ICTACT Journal on Image and Video Processing, 2012 A hybrid image compression method is proposed by which the Nuclei-Cytoplasm of the image is completely restorable and the background part of the image is restorable with insignificant loss.
Y. Jacob Vetha Raj +2 more
doaj
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Adjusting DICOM specifications when using wireless LANs: The MedLAN example [PDF]
, 2003 Wireless networks will become increasingly useful in point-of-care areas such as hospitals, because of their ease of use and their flexibility. A system called MedLAN has been developed by the Central Middlesex Hospital and Brunei University to take ...
Tachakra, S, Song, YH, Banitsas, KA
core +3 more sources
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source