Results 61 to 70 of about 35,976 (328)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Lossy image compression based on prediction error and vector quantisation

EURASIP Journal on Image and Video Processing, 2017
Lossy image compression has been gaining importance in recent years due to the enormous increase in the volume of image data employed for Internet and other applications. In a lossy compression, it is essential to ensure that the compression process does
Mohamed Uvaze Ahamed Ayoobkhan, Eswaran Chikkannan, Kannan Ramakrishnan   +2 more
doaj   +1 more source

Universal Sampling Rate Distortion

, 2017
We examine the coordinated and universal rate-efficient sampling of a subset of correlated discrete memoryless sources followed by lossy compression of the sampled sources.
Boda, Vinay Praneeth, Narayan, Prakash
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Towards decoupling the selection of compression algorithms from quality constraints – an investigation of lossy compression efficiency [PDF]

, 2017
Data intense scientific domains use data compression to reduce the storage space needed. Lossless data compression preserves information accurately but lossy data compression can achieve much higher compression rates depending on the tolerable error ...
Betke, Eugen, Kunkel, Julian Martin, Novikova, Anastasiia   +2 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Statistical mechanics of lossy data compression using a non-monotonic perceptron

, 2002
The performance of a lossy data compression scheme for uniformly biased Boolean messages is investigated via methods of statistical mechanics. Inspired by a formal similarity to the storage capacity problem in the research of neural networks, we utilize ...
C.E. Shannon, C.E. Shannon, C.E. Shannon, D.J.C. MacKay, E. Gardner, E. Yang, G.J. Bex, G.J. Mitchison, H. Nishimori, Hidetoshi Nishimori, J. van Mourik, J.R.L. de Almeida, K. Nokura, N. Sourlas, R. Monasson, T. Murayama, T. Richardson, Tadaaki Hosaka, W. Krauth, W. Krauth, Y. Kabashima, Y. Kabashima, Yoshiyuki Kabashima   +22 more
core   +1 more source

Lossy Compression of Unordered Rooted Trees [PDF]

2016 Data Compression Conference (DCC), 2016
A classical compression method for trees is to exploit subtree repeats in the structure byrepresenting them by directed acyclic graphs. We propose a lossy compression method thatconsists in computing a structure with high redundancy that approximates the initial data.Trees are commonly used to represent hierarchical data appearing in computerscience or
Azaïs, Romain, Durand, Jean-Baptiste, Godin, Christophe   +2 more
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source