Results 81 to 90 of about 522,669 (248)
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Applied SciencesIn the process of data services, compressing and indexing data can reduce storage costs, improve query efficiency, and thus enhance the quality of data services. However, different service requirements have diverse demands for data precision. Traditional
Biao Song +5 more
doaj +1 more source
Adaptive Vector Quantization for Lossy Compression of Image Sequences
Algorithms, 2017 In this work, we present a scheme for the lossy compression of image sequences, based on the Adaptive Vector Quantization (AVQ) algorithm. The AVQ algorithm is a lossy compression algorithm for grayscale images, which processes the input data in a single-
Raffaele Pizzolante +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source
Image Compression Using Integrated Lossless/Lossy Methods
, 1991 A new compression scheme is described that aims at improving the fidelity of reconstructed images through the parallel application of both lossless and lossy compression techniques.
Tzannes, A. P. +2 more
core +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Memory-Efficient Distributed Unlearning
IEEE AccessMachine unlearning considers the removal of the contribution of a set of data points from a trained model, and is often associated with realizing “the right to be forgotten”.
Natalie Lang +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
Subspaces clustering approach to lossy image compression
, 2014 Part 8: Pattern Recognition and Image ProcessingInternational audienceIn this contribution lossy image compression based on subspaces clustering is considered.
Misztal, Krzysztof +5 more
core +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source