Results 81 to 90 of about 931,486 (319)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Statistical mechanical analysis of a hierarchical random code ensemble in signal processing

, 2011
We study a random code ensemble with a hierarchical structure, which is closely related to the generalized random energy model with discrete energy values.
Aji S, Derrida N, Derrida N, Gallager R G, Hayashi M, Kabashima Y, Kabashima Y, Kazutaka Takahashi, Koujin Takeda, Murayama T, Murayama T, Obuchi T, Ogure K, Ogure K, Parisi G, Parisi G, Pasiri G, Shannon C E, Shannon C E, Skantzos N S, Sourlas N, Tomoyuki Obuchi   +21 more
core   +1 more source

ROI coding of volumetric medical images with application to visualisation [PDF]

, 2003
This paper presents region of interest (ROI) coding of volumetric medical images with the region itself being three dimensional. An extension to 3D-SPIHT which allows 3D ROI coding is proposed.
Agrafiotis, D, Bull, DR, Canagarajah, CN
core   +2 more sources

Lossy Image Compression Techniques

International Journal of Computer Applications, 2021
In recent years, domain image processing plays a most significant role in realtime applications. Due to reserved bandwidth and capacity, images are needed to be compressed, enhance, and noise-free to reduce the storage space as well as the transmission time.
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Data Compression with a Time Limit

Algorithms
In this paper, we explore a framework to identify an optimal choice of compression algorithms that enables the best allocation of computing resources in a large-scale data storage environment: our goal is to maximize the efficiency of data compression ...
Bruno Carpentieri
doaj   +1 more source

The compression–error trade-off for large gridded data sets [PDF]

Geoscientific Model Development, 2017
The netCDF-4 format is widely used for large gridded scientific data sets and includes several compression methods: lossy linear scaling and the non-lossy deflate and shuffle algorithms.
J. D. Silver, C. S. Zender
doaj   +1 more source