Results 51 to 60 of about 1,444,956 (266)
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Synthese, 2020 AbstractThis paper develops a puzzle about non-merely-verbal disputes. At first sight, it would seem that a dispute over the truth of an utterance is not merely verbal only if there is a proposition that the parties to the dispute take the utterance under dispute to express, which one of the parties accepts and the other rejects. Yet, as I argue, it is
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Неврология, нейропсихиатрия, психосоматика, 2010 Physicians have been found to be inadequately aware of the structure of the causes of headache, vertigo, and their clinical importance in patients with essential hypertension. Incorrect ideas lead to the unfounded application of diagnostic techniques for
A. E. Manoylov
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
American Journal of Islam and Society, 1999 In Paradise Lost, a collection of rewritten and updated articles spanning a period of twenty-five years, C.A.O. van Nieuwenhuijze attempts to tackle issues of identity and interaction in the Arab-Islamic world.
Amr G. E. Sabet
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Lost to Progress: Upper Mississippi River and Minneapolis Parks Development
Open Rivers, 2017 In February 1872, Horace W. Cleveland trudged through the snowy streets of Minneapolis to the Pence Opera House. His goal was to deliver a speech convincing the city planners, wealthy landowners, and businessmen to work quickly on protecting and ...
Anna Bierbrauer
doaj +1 more source
American Journal of Islam and Society, 2006 Yvonne Corcoran-Nantes’ Lost Voices: Central Asian Women Confronting Transition examines how the Soviets empowered and disempowered Central Asian women before, during, and after the communist regime.
Erica Marat
doaj +1 more source