Results 51 to 60 of about 5,808,650 (308)

Lost in Conversation [PDF]

, 2017
While still in the midst of their study abroad experiences, students at Linfield College write reflective essays. Their essays address issues of cultural similarity and difference, compare lifestyles, mores, norms, and habits between their host countries
Henley, Kate
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Has education lost sight of children? [PDF]

, 2018
The reflections presented in this chapter are informed by clinical and personal experiences of school education in the UK. There are many challenges for children and young people in the modern education system and for the professionals who support them ...
A Bandura, A Bernier, A Binet, A Caspi, A Schore, AJ Sameroff, B Bradbury, B Egeland, BD Perry, C Robinson, C Sharp, C Spearman, CS Dweck, D Elkind, D Elkind, D Goleman, DJ Siegel, E Smyth, ED Babcock, GJ Duncan, GJ Duncan, H Eysenck, H Gardner, H Gardner, H Gardner, H Gardner, H Gardner, H Gardner, I Deary, J Barlow, J Belsky, J Belsky, J Brooks-Gunn, J Brooks-Gunn, J Piaget, J Piaget, J Price, J Scott, J Waldfogel, JH Goldthorpe, JP Shonkoff, JP Shonkoff, K Hansen, K Hoeve, K Riley, K Robson, L Feinstein, LS Vygotsky, M Evans, MA Sheridan, MJ Guralnick, NICE, P Bourdieu, P Fonagy, P Normak, P Özdemir, PR Amato, RJ Davidson, RJ Herrnstein, S Duchesne, S Gerhardt, S Moulin, S Tunnard, SF Reardon, SH Landry, SS Luthar, T Tough, TR Hoerr, U Bronfenbrenner, U Neisser, V Ramos-Ford, VB Emig, WB Elley   +72 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Paradise Lost: The Struggle to Preserve the Pongola River and its Inhabitants

Open Rivers, 2018
In December of 2016, I went on the journey of a lifetime to kwaZulu-Natal, South Africa on a faculty-led excursion titled “Summits to Sea” with Virginia Commonwealth University (VCU).
Shira Lanyi
doaj   +1 more source

Efeito da Universidade Aberta à Terceira Idade sobre a qualidade de vida do idoso

Educação e Pesquisa, 2017
Resumo A educação na velhice tem como finalidade promover conhecimentos que determinam redimensionamentos para o fomento da qualidade de vida a partir de pressupostos de interdisciplinaridade, participação social e promoção da saúde.
Keika Inouye, Fabiana de Souza Orlandi, Sofia Cristina Lost Pavarini, Elisete Silva Pedrazzani   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source