Results 21 to 30 of about 89,974 (258)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Machine learning-based diagnosis of fracture-induced lost circulation and intelligent selection of lost circulation control fluids

Meitian dizhi yu kantan
Objective and Method Drilling operations in the Changqing area face several challenges in lost circulation, including complex types, significantly different characteristics, and difficulty in designing plugging formulations. To address these issues, this
Huan SUN, Mingming ZHU, Jinshu WANG, Lu YAO, Fangfang ZHOU, Xuebin TAN, Yan SUN, Yanping QU, Ning CHEN   +8 more
doaj   +1 more source

Application of adaptive neuro-fuzzy inference system and data mining approach to predict lost circulation using DOE technique (case study: Maroon oilfield)

Petroleum, 2020
Lost circulation is the most common problem encountered while drilling oil wells. Occurrence of such a problem can cause a lot of time and cost wastes.
Farough Agin, Rasool Khosravanian, Mohsen Karimifard, Amirhosein Jahanshahi   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Formulation Design of Drilling Fluid Loss Control and Plugging Strategies in Deepwater Subsalt Reservoirs

Zuanjingye yu wanjingye
Subsalt oil and gas resources are abundant worldwide, with significant reserves located in the deepwater offshore regions of Brazil. The Mero field is a typical example of deepwater subsalt oil and gas resources, located in the southeastern Santos Basin ...
Chengyuan XU, Jiangcheng ZHONG, Haifeng ZHU, Ming XIANG, Zhiqiang LIN, Jie YANG, Jiaxu CHEN   +6 more
doaj   +1 more source

Data–driven decision–making for lost circulation treatments: A machine learning approach

Energy and AI, 2020
Lost circulation is an expensive and critical problem in the drilling operations. Millions of dollars are spent every year to mitigate or stop this problem. In this work, data from over 3000 wells were collected from multiple sources.
Husam H. Alkinani, Abo Taleb T. Al-Hameedi, Shari Dunn-Norman   +2 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Experimental Study on Lost Circulation Control with Particle-Gel Composite Plugging on a Novel Dynamic Circulating Lost Circulation Device

Zuanjingye yu wanjingye
Experimental devices currently in use for lost circulation control test have such shortages in simulating dynamic circulation and evaluating the performance of lost circulation slurries.
Zhaowen HU, Yiqun ZHANG, Yanjun LIU, Xinyu WANG, lili YANG, Ya LIU   +5 more
doaj   +1 more source