Results 21 to 30 of about 53,909 (251)

Experimental Investigation of Particle Size Degradation and Plugging Efficiency of Three Granular Lost Circulation Materials

Applied Sciences, 2021
This work delineates a comprehensive study of one of the main problems that contributes towards nonproductive time (NPT) in a drilling operation, which is lost circulation.
Saleh A. Alhaidari, Sulaiman A. Alarifi
doaj   +1 more source

Preparation and Degradation Performance Study of P(AM/GG/PEGDA) Nanocomposite Self-Degradation Gel Plugging Material

Gels, 2023
Lost circulation is a world-class problem, and the contradiction between plugging and unplugging in reservoirs is a problem that needs to be solved urgently.
Dan Bao, Siyuan Liu, Xianli Zhang, Feng Li, Jiaqin Wang, Huan Jia, Shanghao Liu, Peng Zhang   +7 more
doaj   +1 more source

Structural failure mechanism and strengthening method of fracture plugging zone for lost circulation control in deep naturally fractured reservoirs

Petroleum Exploration and Development, 2020
Focused on the lost circulation control in deep naturally fractured reservoirs, the multiscale structure of fracture plugging zone is proposed based on the theory of granular matter mechanics, and the structural failure pattern of plugging zone is ...
Chengyuan XU, Xiaopeng YAN, Yili KANG, Lijun YOU, Jingyi ZHANG   +4 more
doaj   +1 more source

Formation mechanisms of fracture plugging zone and optimization of plugging particles

Petroleum Exploration and Development, 2022
As formation mechanisms of plugging zone and criteria for fracture plugging remain unclear, plugging experiments and methods testing granular material mechanical properties are used to study the formation process of the plugging zone in fractured ...
Shaofei LEI, Jinsheng SUN, Yingrui BAI, Kaihe LYU, Shupei ZHANG, Chengyuan XU, Rongchao CHENG, Fan LIU   +7 more
doaj   +1 more source

Preparation and Application of a Controlled-Setting Lost-Circulation Material for Severe Lost Circulation

Applied Sciences
To address the challenges associated with severe lost-circulation formations, including large loss-channel dimensions, rapid fluid losses, and the tendency of conventional bridging or physical-filling materials to accumulate at fracture entrances rather ...
Hongjun Wu, Bao Zhang, Jianxin Shen, Jiaxin Tang, Dingdong Mo, Yingrui Bai, Junyi Wu   +6 more
doaj   +1 more source

Performance Evaluation Of The New Natural And Environmentally Friendly Material For Lost Circulation Control At High Pressure And Hight Temperature

Eurasian Journal of Science and Engineering, 2023
Lost circulation refers to the loss of a part or whole drilling fluid into the formation and is considered as one of the most challenges in drilling operations. It could be occurred either naturally in highly fractured formations or induced by excessive
Pshtiwan T. Jaf, Ayad A. A.Alrazzaq, Jafar A. Ali   +2 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source