Results 111 to 120 of about 6,364,937 (291)

A Self-Adaptable High Pressure Bearing Plugging Agent for Synthetic-Based Drilling Fluid in Shallow Extended-Reach Well Drilling in Bohai

Zuanjingye yu wanjingye
The direction in which the properties of the self-adaptable high pressure bearing plugging agent are specifically optimized is understood by analyzing the lost circulation scenarios occurring in shallow extended-reach well drilling in Bohai area, that is,
Baosheng LIU, Baisong TANG, Hongbo HUO, Jun ZHANG, Xinxin HOU, Yinbo HE, Yijie WANG   +6 more
doaj   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

Understanding Lost Circulation While Cementing: Field Study and Laboratory Research

, 2018
Summary Lost circulation is a time-consuming and expensive challenge, costing the oil and gas industry billions of dollars each year in materials, nonproductive time, and minimized production (Catalin et al. 2003; Fidan et al. 2004; API 65-
S.. Taoutaou, S. G. James, P. W. Way, E.. Therond, A.. Dondale, P.. Gomes   +5 more
core   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Experimental investigation of deformable additives as loss circulation control agent during drilling and well construction

Scientific Reports
Lost circulation is known as one of the most important challenges during drilling. In addition to high costs due to mud loss and nonproductive time, lost circulation may lead to several consequences, including stuck pipes, wellbore collapse, poor hole ...
Rasoul Nazemi, Ghasem Zargar, Vahid Nooripoor   +2 more
doaj   +1 more source

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

Evaluation of Lost Circulation Material Sealing for Geothermal Drilling

Energies
Lost circulation is a pervasive problem in geothermal wells that can create prohibitive costs during drilling. The main issue with treatment is that the mechanism of plug formation is poorly understood. Here we applied two experimental approaches to characterize the clogging effectiveness of different materials.
William Kibikas, Seiji Nakagawa, Mathew Ingraham, Stephen Bauer, Chun Chang, Patrick Dobson, Timothy Kneafsey, Abraham Samuel   +7 more
openaire   +2 more sources

Investigation of lost circulation materials impact on fracture gradient [PDF]

, 2015
Lost circulation is a challenging problem to be prevented or mitigated during drilling. Lost circulation treatments are widely applied to mitigate losses using a corrective approach or to prevent losses using preventive approaches, also known as ...
Alsaba, Mortadha Turki
core  

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source

Lost circulation in geothermal wells: research and development status

, 1985
The most common severe problems encountered in drilling and completing geothermal wells are lost circulation (loss of fluid returns to the surface), stuck pipe, and inadequate cementing.
Satrape, J. V., Caskey, B. C.
core