Results 131 to 140 of about 86,998 (307)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Multi-Level Lot Sizing Problem with Deterioration Inventory and Disposal Costs
مدیریت تولید و عملیات, 2016 In this paper, the multi-level lot sizing problem which is used to determine the production lot sizes in industrial environments, has been investigated.
Mahmood Vahdani, Ardeshir Dolati
doaj
Sustainable dynamic lot sizing models for cold products under carbon cap policy. [PDF]
Comput Ind Eng, 2020 As'ad R, Hariga M, Shamayleh A.
europepmc +1 more source
Improved Lower Bounds For The Capacitated Lot Sizing Problem With Set Up Times [PDF]
We present new lower bounds for the Capacitated Lot Sizing Problem with Set Up Times. We improve the lower bound obtained by the textbook Dantzig-Wolfe decomposition where the capacity constraints are the linking constraints.
Degraeve, Z., Jans, R.F.
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Multi-level lot sizing: A literature survey
, 2017 Lot sizing certainly belongs to the most established production planning problems. First scientific reports of this subject date from the beginning of the 20th century and at least one chapter about lot sizing can be found in almost every good textbook ...
Drexl, Andreas, Kimms, Alf
core
Modeling Industrial Lot Sizing Problems: A Review [PDF]
, 2005 In this paper we give an overview of recent developments in the field of modeling single-level dynamic lot sizing problems. The focus of this paper is on the modeling various industrial extensions and not on the solution approaches.
Degraeve, Z. (Zeger), Jans, R.F. (Raf)
core +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
An Improved WAGNER-WHITIN Algorithm
International Journal of Industrial Engineering and Production Research, 2009 We present an improved implementation of the Wagner-Whitin algorithm for economic lot-sizing problems based on the planning-horizon theorem and the Economic- Part-Period concept.
S. J Sadjadi +2 more
doaj
The collaborative multi-level lot-sizing problem with cost synergies. [PDF]
Int J Prod Res, 2020 Gansterer M, Hartl RF.
europepmc +1 more source