Results 81 to 90 of about 3,141 (216)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Remanufacturing lot-sizing under alternative perceptions of returned units' quality [PDF]
International Journal of Business Science and Applied Management, 2012 One of the critical parameters in reverse supply chain management is the increased variability of the quality condition of used, returned products. The volatile nature of returns' quality often dictates the establishment of quality assessment procedures ...
Zikopoulos, C.
doaj
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Multi-Level Lot Sizing Problem with Deterioration Inventory and Disposal Costs
مدیریت تولید و عملیات, 2016 In this paper, the multi-level lot sizing problem which is used to determine the production lot sizes in industrial environments, has been investigated.
Mahmood Vahdani, Ardeshir Dolati
doaj
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Spektrum Industri: Jurnal Ilmiah Pengetahuan dan Penerapan Teknik Industri, 2015 Material Requirement Planning (MRP) adalah suatu metode yang digunakan untuk mengendalikan persediaan bahan baku pada perusahaan. Suatu perusahaan untuk menerapkan kebijakan-kebijakan dalam perencanaan bahan baku harus memiliki perhitungan yang tepat ...
Asvin Wahyuni, Achmad Syaichu
doaj
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Sustainable dynamic lot sizing models for cold products under carbon cap policy. [PDF]
Comput Ind Eng, 2020 As'ad R, Hariga M, Shamayleh A.
europepmc +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source