Results 11 to 20 of about 108 (92)

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

CNC–PNIPAM Drug Delivery System Improves Endometrial Receptivity via Natural Killer Cell Immune Tolerance in Endometriosis

Advanced NanoBiomed Research, EarlyView.
An injectable CNC–PNIPAM hydrogel is developed for intrauterine co‐delivery of levonorgestrel and botropase. This platform reprograms uterine natural killer cells toward an immune–tolerant phenotype and enhances endometrial receptivity marker expression. The results demonstrate a promising strategy to counteract endometriosis–associated infertility and
Zhou Liang, Yingjie Wang, Chenyu Bai, Pengfei Li, Xin He, Meng Ma, Xiaoying Luo, Yi Song, Yao Li, Yun Wang   +9 more
wiley   +1 more source

Estimation and rapid identification of later stages during embryonic development of the oviparous lizard Sceloporus aeneus (Squamata: Phrynosomatidae)

The Anatomical Record, EarlyView.
Abstract Stages of embryonic development for reptiles have been presented in tables that may include all or part of embryonic development. When oviposition occurs in some lizards, embryos are already in the later stages of development; likewise, the size of the eggs increases as incubation time progresses.
Nivia Rocio Antonio‐Rubio, Maricela Villagrán‐SantaCruz, Martha Elena Díaz‐Hernández, Norma Moreno‐Mendoza   +3 more
wiley   +1 more source

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

Positive Constructs in Schema Therapy: A Scoping Review

Journal of Clinical Psychology, EarlyView.
ABSTRACT Central to the schema therapy model is the development of early maladaptive schemas due to unmet emotional needs in childhood. Recently, focus has shifted towards positive constructs in schema therapy, including early adaptive schemas or positive schemas and positive schema modes, such as the “healthy adult” and “happy child.” This scoping ...
Loes van Donzel, Anne‐Marie Claassen, Machteld A. Ouwens, Jenny Broersen, Sebastiaan P. J. van Alphen, John P. Louis, Arjan C. Videler   +6 more
wiley   +1 more source

Caloric restriction‐mediated reproductive lifespan extension across multiple strains of the clonal aquatic plant Lemna turionifera

Oikos, EarlyView.
Lifespan extension due to caloric restriction (CR) is a well‐established aspect of animal senescence that has been observed in many taxa. Contrastingly, there is much less evidence in plants, even though it is straightforward to manipulate CR by restricting photosynthesis through reduction in light intensity.
Julian A. Ketler, Nicola M. Herman, Suzanne L. Chmilar, Robert A. Laird   +3 more
wiley   +1 more source

Sustainable treatment of banana leaves for phytosanitary applications: impact, spreading, and impregnation of mineral oil

Pest Management Science, EarlyView.
Mineral oil droplets spread anisotropically, penetrate banana leaf tissues, and diffuse into the palisade parenchyma, revealing a delayed, Fickian mechanism that supports improved phytosanitary spray strategies. Abstract BACKGROUND Efficient application of phytosanitary sprays is essential for sustainable control of foliar fungal diseases such as Black
Abdallah Alayan, Stéphane Boyer, Jean‐Luc Verdeil, Fréderic Gatineau, Patrick Hermet, Jean‐Louis Bantignies, Christian Ligoure   +6 more
wiley   +1 more source

In Defence of Food: A Comparative Study of Conversas' and Moriscas' Dietary Laws as a Form of Cultural Resistance in the Early Modern Crown of Aragon

Gender &History, EarlyView.
ABSTRACT This research explores the adaptive strategies employed by Conversas (Christian women of Jewish origin) and Moriscas (Christian women of Muslim origin) in navigating adversity, particularly in their interactions with inquisitorial authorities in the early modern Crown of Aragon. This study analyses these women's efforts to uphold religious and
Ivana Arsić
wiley   +1 more source