Results 91 to 100 of about 319,004 (304)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Ankara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Dergisi, 2017 This article applies one aspect of Jean-Paul Sartre’s existentialist approach as found in his philosophic masterpiece Being and Nothingness to a particularly prevelant pair of characters in classical Near Eastern poetry.
Fatma DORE
doaj
Los celos en Proust y Shakespeare: un caso de voyeurismo narrativo
Anuario de Letras Modernas, 2009 Voyeurism is often the mise en scene the jealous man builds in his imagination both to goad and relish in his anguish at the thought of his/her beloved being possessed by the rival—real or imaginary.
Luz Aurora Pimentel
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Truth and Love in Sexual Ethics of Islam [PDF]
, 2017 Tulisan ini berpretensi untuk mengelaborasi salah satu unsur penting dalam etika seksual Islam yakni cinta untuk memperkuat dasar pernikahan. Cinta adalah dialog dan perjumpaan antara dua ‘Aku” yang kemudian melebur dalam ke-aku-an kekasih. Pandangan ini
Munfarida, E. (Elya) +2 more
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Tancerz i szachista w świecie słów
Między Oryginałem a PrzekłademDANCER AND CHESS PLAYER IN A WORLD OF WORDS This article is devoted to Andrzej Lewandowski, a translator from Toruń born in 1937, a doctor of mathematics, an outstanding chess player, and a lover of Italy, music, and mountains, among other things.
Monika Krajewska
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Preference for Information and Dynamic Consistency [PDF]
We provide necessary and sufficient conditions for a dynamically consistent agent always to prefer more informative signals (in single-agent problems). These conditions do not imply recursivity, reduction or independence.
Atsushi Kajii, Ben Polak, Simon Grant
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source