Results 241 to 250 of about 10,014,931 (288)

The strength of a low-barrier hydrogen bond in water

Tetrahedron Letters, 2002
Abstract There are large differences between the acidity of the enol of the acyclic diketone, 2,4-pentanedione and those of two cyclic diketones, 1,3-cyclopentanedione and 1,3-cyclohexanedione. Computational studies have demonstrated that these differences are largely due to the strength of the internal low-barrier hydrogen bond (LBHB) in the enol of
James R Keeffe, Freeman M Wong
exaly   +2 more sources

Low-barrier hydrogen bonds in proteins

Crystallography Reviews, 2013
Hydrogen bonding interactions are one of the most important chemical interactions among materials, especially biological materials, which help confer specificity, which is crucial for their efficient functioning. Recently, low-barrier hydrogen bonds (LBHBs) have been proposed to play a critical role in enzyme catalysis.
Samarth Hegde   +2 more
exaly   +2 more sources

A low-barrier hydrogen bond in the catalytic triad of serine proteases

Science, 1994
Spectroscopic properties of chymotrypsin and model compounds indicate that a low-barrier hydrogen bond participates in the mechanism of serine protease action. A low-barrier hydrogen bond between Nδ1 of His 57 and the β-carboxyl group of Asp 102 in chymotrypsin can facilitate the formation of
Perry A Frey, P A Frey
exaly   +3 more sources

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