Results 271 to 280 of about 10,014,931 (288)
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Low-Barrier Hydrogen Bond in the Catalytic Triad of Serine Enzymes
1998Acetylcholinesterase (AChE) and chymotrypsin are serine enzymes whose catalytic mechanism involves a nucleophilic attack (serine) and a general acid-base moiety (histidine). The incipient imidiazolium which is formed as a result of the nucleophilic attack by serine is stabilized by the negatively charged carboxylate (Glu or Asp).
Rohit Medhekar +4 more
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Are There Really Low-Barrier Hydrogen Bonds in Proteins? The Case of Photoactive Yellow Protein
Journal of the American Chemical Society, 2014For a long time, low-barrier hydrogen bonds (LBHBs) have been proposed to exist in many enzymes and to play an important role in their catalytic function, but the proof of their existence has been elusive. The transient formation of an LBHB in a protein system has been detected for the first time using neutron diffraction techniques on a photoactive ...
Marc, Nadal-Ferret +3 more
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Spectral Signatures of Proton-Transfer Dynamics at the Cusp of Low-Barrier Hydrogen Bonding
The Journal of Physical Chemistry Letters, 2018Despite their importance in diverse chemical and biochemical processes, low-barrier hydrogen bonds remain elusive targets to classify and interpret spectroscopically. Here the correlated nature of hydrogen bonding and proton transfer in the low-barrier regime has been probed for the ground and excited electronic states of 6-hydroxy-2-formylfulvene by ...
Zachary N. Vealey +2 more
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A New Concept for the Mechanism of Action of Chymotrypsin: The Role of the Low-Barrier Hydrogen Bond
Biochemistry, 1997The basicities of the diad H57-D102 at N(epsilon)2 in the tetrahedral complexes of chymotrypsin with the peptidyl trifluoromethyl ketones (TFK) N-acetyl-L-Leu-DL-Phe-CF3 and N-acetyl-DL-Phe-CF3 have been studied by 1H-NMR. The protons bridging His 57 and Asp 102 in these complexes are engaged in low-barrier hydrogen bonds (LBHBs).
C S, Cassidy, J, Lin, P A, Frey
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Transient low-barrier hydrogen bond in the photoactive state of green fluorescent protein
Physical Chemistry Chemical Physics, 2015A transient low-barrier hydrogen bond has been found directly after photoexcitation using quantum dynamics to study the excited-state process in GFP.
Marc Nadal-Ferret +3 more
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Follow the Protons: A Low-Barrier Hydrogen Bond Unifies the Mechanisms of the Aspartic Proteases
Accounts of Chemical Research, 2001Seven proton transfers in five steps participate in a catalytic turnover of an aspartic protease. The Rosetta Stone for elucidating their role is a low-barrier hydrogen bond that holds the two aspartic carboxyls in a coplanar conformation. The proton of this bond shuttles between oxygens during chemical steps via hydrogen tunneling, unlike in previous ...
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On the Possibility of Using UV Spectroscopy as a Measure of the Low-Barrier Hydrogen Bond
Structural Chemistry, 2003Christopher J Halkides, Michael Messina
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