Results 81 to 90 of about 302,850 (308)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Low-Cost Smart Sensor Network for Catchment Monitoring

Sensors, 2019
Understanding hydrological processes in large, open areas, such as catchments, and further modelling these processes are still open research questions.
Dian Zhang, Brendan Heery, Maria O’Neil, Suzanne Little, Noel E. O’Connor, Fiona Regan   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Low Cost Optical-electronic Sensor Development Based on Raman Spectroscopy for Liquid

JAREE (Journal on Advanced Research in Electrical Engineering), 2020
Spectroscopy is a method that used to identify chemical structure of substances using its spectral pattern characteristics. Optical spectroscopy term can be applied to any kind of optical photon interactions with matter.
Luqman Aji Kusumo, Totok Mujiono, Hendra Kusuma   +2 more
doaj   +1 more source

A Low Cost Three-Directional Force Sensor [PDF]

International Journal on Smart Sensing and Intelligent Systems, 2011
Abstract In this work a low cost sensor has been developed to measure three-directional forces. The theory, design and sensor construction details are presented. It was constructed by using commercial strain gauges. Finite element method was adopted to optimize the structure dimensions, and improve the sensitivity of force sensor by ...
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Photovoltaic sample-and-hold circuit enabling MPPT indoors for low-power systems [PDF]

, 2012
Photovoltaic (PV) energy harvesting is commonly used to power autonomous devices, and maximum power point tracking (MPPT) is often used to optimize its efficiency. This paper describes an ultra low-power MPPT circuit with a novel sample-and-hold and cold-
Weddell, Alex S., Merrett, Geoff V., Al-Hashimi, Bashir M.   +2 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Application of a microflown as a low-cost level sensor

Journal of Micromechanics and Microengineering, 2000
In this paper we present a novel 'spirit level' sensor derived from a well known thermal flow sensor. The operation principle is based on the temperature difference of two identical heaters, caused by buoyancy of air. Heating as well as temperature sensing of the structures is carried out temperature-dependent platinum resistors.
van Honschoten, J.W., van Baar, J.J.J., de Bree, H.E., Lammerink, T.S.J., Krijnen, G.J.M., Elwenspoek, M.C.   +5 more
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source