Results 101 to 110 of about 1,184,339 (384)
Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules
Advanced Materials Interfaces, EarlyView.This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania +2 more
wiley +1 more source
Extracellular Matrix Targeted MRI Probes
Analysis &Sensing, Volume 3, Issue 1, January 2023., 2023 Gadolinium based MRI probes targeted to ECM components, either proteins or enzymes, hold promise for accurate molecular characterization and staging of fibrotic diseases in vivo. Non‐covalent binding probes (1), reactive probes (2), and enzyme‐responsive probes (3) are discussed.
Giuseppe Digilio +3 more
wiley +1 more source
Journal of Cell Biology, 1984 Acetylated-low density lipoprotein (Ac-LDL) is taken up by macrophages and endothelial cells via the "scavenger cell pathway" of LDL metabolism. In this report, aortic and microvascular endothelial cells internalized and degraded 7-15 times more [125I ...
J. Voyta +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley +1 more source
Regression with a right-censored predictor, using inverse probability weighting methods [PDF]
arXiv, 2020 In a longitudinal study, measures of key variables might be incomplete or partially recorded due to drop-out, loss to follow-up, or early termination of the study occurring before the advent of the event of interest. In this paper, we focus primarily on the implementation of a regression model with a randomly censored predictor.
arxiv
Proceedings of the National Academy of Sciences of the United States of America, 1990 After exposure to low density lipoprotein (LDL) that had been minimally modified by oxidation (MM-LDL), human endothelial cells (EC) and smooth muscle cells (SMC) cultured separately or together produced 2- to 3-fold more monocyte chemotactic activity ...
S. D. Cushing +8 more
semanticscholar +1 more source
Nanotherapy for Neural Retinal Regeneration
Advanced Science, EarlyView.Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu +11 more
wiley +1 more source
Role of oxidised low density lipoprotein in atherogenesis.
British heart journal, 1993 Overview of the concept ofoxidative modification ofLDL There can be no doubt now that there is a continuum of increasing risk for complications ofatherosclerosis when plasma cholesterol levels exceed 160-180 mg/dl. Many types of experimental and clinical
J. Witztum
semanticscholar +1 more source
Advanced Science, EarlyView.VPS72 overexpression activates mTORC1 signaling, subsequently promoting lipid synthesis and driving HCC progression. VPS72 modulates the epigenetic landscape of ATF3 promoter, such as H2A.Z acetylation reduction and DNA methylation increase, which results in ATF3 repression and subsequent activation of mTORC1.
Qinglin Zhang +4 more
wiley +1 more source
Journal of Lipid Research, 2005 The proportion of the electronegative low density lipoprotein [LDL(−)] subfraction, which is atherogenic, is increased in type 2 diabetes but is not reduced by glycemic control.
Bo Zhang +3 more
doaj