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Effects of low-intensity focused ultrasound on the mouse submandibular gland
Ultrasound in Medicine & Biology, 2006Ultrasound is expected to make a considerable contribution to drug delivery systems (DDSs). We tested the hypothesis that low-intensity focused ultrasound (LIFU) increases vessel permeability in the mouse submandibular gland without causing parenchymal damage.
Jun, Shuto +2 more
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Low Intensity Focused Ultrasound Modulation of Neural Circuits Activity
2019 IEEE 6th Portuguese Meeting on Bioengineering (ENBENG), 2019Ultrasound neuromodulation (UNMOD) has gained popularity as a new state-of-the-art technique for the research and treatment of neurological and psychiatric illnesses. Ultrasounds (US) can be transmitted in a noninvasive manner to deep-brain regions with a focus of a few millimeters in size.
Machado, Francisca +3 more
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Preliminary study on Low Intensity Focused Ultrasound system For neuromodulation
2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2017A Prototype Low Intensity Focused Ultrasound for brain targeting in a rat model was developed and tested. Accordingly, were evaluated low intensity focused ultrasound accuracy and performance. By utilizing the Rat Brain, no death or necrosis of cells, it was confirmed that the energy is gathered at that targeted.
Ju-Hyung Lee +6 more
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Progress in Noninvasive Low-Intensity Focused Ultrasound Neuromodulation
StrokeLow-intensity focused ultrasound represents groundbreaking medical advancements, characterized by its noninvasive feature, safety, precision, and broad neuromodulatory capabilities. This technology operates through mechanisms, for example, acoustic radiation force, cavitation, and thermal effects.
Jinru Feng, Zixiao Li
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Beamforming Design for High-Resolution Low-Intensity Focused Ultrasound Neuromodulation
ICASSP 2020 - 2020 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), 2020Low-intensity focused ultrasound (LIFU) has been shown to modulate neural activity. Recent experiments suggest potential applications of LIFU stimulation for treating neuropsychiatric disorders like depression and Alzheimer’s. The modulation effect is usually positively correlated with the ultrasound intensity, and there exists a minimum intensity ...
Boqiang Fan +5 more
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A Review of Mechanistic Effects of Low-Intensity Focused Ultrasound
Neuromodulation: Technology at the Neural InterfaceLow-intensity focused ultrasound (LIFU) has become increasingly used in neuromodulation. However, its mechanisms of action are less well understood. Here, we provide a scoping review of the effects of LIFU on nervous system tissue.We evaluated the PubMed, SCOPUS, and Web of Science data bases for articles using the keywords related to LIFU and ...
Pravarakhya Puppalla +6 more
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A Prototype Stimulator System for Noninvasive Low Intensity Focused Ultrasound Delivery
2012A prototype Low Intensity Focused Ultrasound (LIFU) stimulator system was developed to evaluate non-invasive neuromodulation in a large animal model. We conducted a feasibility study on a Göttingen minipig, demonstrating reversible, targeted transcranial neuromodulation. The hypothalamus of the minipig was repeatedly stimulated with LIFU which
Amit P. Mulgaonkar +9 more
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Low Intensity Transcranial Focused Ultrasound in Patients with PTSD
2023We are investigating the feasibility of using transcranial focused ultrasound of the amygdala to change amygdala activity and psychophysiological arousal in patients with posttraumatic stress disorder (PTSD). We will also investigate if changes in amygdala activity will correspond with changes in PTSD symptoms.
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Repeated neuromodulation with low-intensity focused ultrasound in patients with Alzheimer's disease
Journal of Alzheimer’s DiseaseBackground Low-intensity focused ultrasound (LIFU), a non-invasive targeted brain stimulation technology, has shown promise for therapeutic applications in Alzheimer's disease (AD) patients. Despite its potential, the implications of repeated LIFU neuromodulation in AD patients remain to be investigated.
Hyeonseok Jeong +9 more
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