Results 41 to 50 of about 709,749 (267)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Design of Low-power Consumption Front-end CMOS Chip Circuit for Boron Nitride Personal Dosimeter

open access: yesYuanzineng kexue jishu
In the context of radiation monitoring for occupational safety, personal dosimeters require highly sensitive and energy-efficient electronic interfaces.
LIU Zhan, LIU Haifeng, HE Gaokui, HUANG Xinyi, SUN Jiayu
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Differential ultra low noise amplifier for low frequency noise measurements

open access: yesAIP Advances, 2011
Almost all low noise voltage preamplifier suitable for application in the field of Low Frequency Noise Measurements (either commercially available or proposed in the literature) are single ended input amplifiers.
Graziella Scandurra   +2 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Gm-boosted Flat Gain UWB Low Noise Amplifier with Noise Cancellation

open access: yesChemical Engineering Transactions, 2015
This paper presents a high power gain (S21) and low Noise Figure (NF) 3.1-10.6 GHz common gate (CG) CMOS ultra wideband (UWB) low noise amplifier (LNA) using active gm-boosted technology, T-match input network, self-body-bias, current reused and noise ...
X.R. Zhao   +4 more
doaj   +1 more source

A low‐noise current‐reused CMOS active inductor by exploiting Gm‐boosting technique

open access: yesIET Microwaves, Antennas & Propagation, 2021
This work introduces a new low‐noise current‐reused CMOS active inductor (AI) based on Gyrator‐C configuration. In the proposed AI, a simple common‐source amplifier is utilised for boosting effective Gm and improving noise performance of the AI.
Abdollah Sabbaghi, Emad Ebrahimi
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Advancements in Neural Recording Circuits: Review of Nerve Biopotentials, and Neural Recording Circuit Architectures

open access: yesIEEE Access
Peripheral nerve injuries pose significant health challenges leading to loss of motor control and sensation. These injuries can result from trauma, surgery, tumors, and neurological disorders.
Malak Mneimneh   +2 more
doaj   +1 more source

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