Results 51 to 60 of about 849,396 (352)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

UWB-MMIC Matrix Distributed Low Noise Amplifier

Proceedings, 2020
In this paper, a 3.1–11 GHz ultra-wideband low noise amplifier with low noise figure, high power gain S21, low reverse gain S12, and high linearity using the OMMIC ED02AH process, which employs a 0.18 μm Pseudomorphic High Electron Mobility Transistor is
Moustapha El Bakkali, Said Elkhaldi, Intissar Hamzi, Abdelhafid Marroun, Naima Amar Touhami   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A Low Noise Receiver for Submillimeter Astronomy [PDF]

, 1986
A broadband, low noise heterodyne receiver, suitable for astronomical use, has been built using a Pb alloy superconducting tunnel junction (SIS). The RF coupling is quasioptical via a bowtie antenna on a quartz lens and is accomplished without any tuning
Miller, R. E., Phillips, T. G., Wengler, M. J., Woody, D. P.   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Design of Low-power Consumption Front-end CMOS Chip Circuit for Boron Nitride Personal Dosimeter

Yuanzineng kexue jishu
In the context of radiation monitoring for occupational safety, personal dosimeters require highly sensitive and energy-efficient electronic interfaces.
LIU Zhan, LIU Haifeng, HE Gaokui, HUANG Xinyi, SUN Jiayu
doaj   +1 more source

LOW FREQUENCY NOISE - AN INVENTORY OF THE LITERATURE AND OF THE SITUATION IN THE NETHERLANDS [PDF]

, 2023
Kim White, Anja Versteeg, Angela Kok, Ric van Poll, A Dusseldorp   +4 more
openalex   +1 more source

Large-Area, Low-Noise, High Speed, Photodiode-Based Fluorescence Detectors with Fast Overdrive Recovery

, 2005
Two large-area, low noise, high speed fluorescence detectors have been built. One detector consists of a photodiode with an area of 28 mm x 28 mm and a low noise transimpedance amplifier.
D. DeMille, Graeme J., Horowitz P., S. Bickman, Yariv A.   +4 more
core   +3 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source