Results 51 to 60 of about 709,749 (267)

Low Noise Low Power CMOS Telescopic-OTA for Bio-Medical Applications

Computers, 2016
The preamplifier block is crucial in bio-medical signal processing. The power intensive Operational Transconductance Amplifier (OTA) is considered, and the performance of preamplifier is studied.
Bellamkonda Saidulu, Arun Manoharan, Kumaravel Sundaram   +2 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Bandgap-Tuned Yttrium-Doped Indium Oxide Alloy Thin Films for High-Performance Solar-Blind Ultraviolet Photodetectors

Technologies
Yttrium oxide (Y2O3) has emerged as a key material for advanced solar-blind ultraviolet (SBUV) photodetectors, attributable to its large bandgap energy (~5.5 eV), high dielectric constant, excellent silicon compatibility, and robust thermal stability. To
Lu Gan, Peicheng Jiao, Zhengdong Jiang, Yutao Xiong, Yanghui Liu   +4 more
doaj   +1 more source

A low power low noise eight-phase output ring oscillator

Dianzi Jishu Yingyong, 2018
Aiming at the problems of the ring oscillator such as large power consumption, loud noise, linearity deficiency etc., a novel ring oscillator with cross feed forward structure is proposed based on TSMC 55 nm process.
Li Xin, Zhang Haining, Liu Min
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Design of a Scalable Modular Bias Voltage Supply With Reduced Noise for Multi-Channel SiPM Readout

IEEE Access
This work presents the design and characterization of a modular, digitally programmable Voltage Supply Unit (VSU) optimized for Silicon Photomultiplier (SiPM) arrays in high-sensitivity applications such as cryogenic particle detectors.
Davide Colaiuda, Alfiero Leoni, Sosuke Horikawa, Giuseppe Ferri, Vincenzo Stornelli   +4 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source