Results 51 to 60 of about 173,922,819 (209)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Energies, 2020 In this study, we investigate a numerical-modeling method uniquely performing analyses of 50 different metal hydrides to find the optimized thermal effect.
Suyun Ham, Sanggoo Kang, Kyu-Jung Kim
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
A study of trilateral flash cycles for low-grade waste heat recovery-to-power generation [PDF]
, 2014 There has been renewed significance for innovative energy conversion technologies, particularly the heat recovery-to-power technologies for sustainable power generation from renewable energies and waste heat. This is due to the increasing concern over
Ajimotokan, Habeeb A.
core +3 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Applied SciencesThis study focuses on the genesis mechanism of thermal anomalies in the southwestern part of the Anan Depression in the Erlian Basin. Based on magnetotelluric 3D inversion data, a high-resolution electrical resistivity structure model was constructed ...
Sen Wang +4 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Zhongguo dianliAt present, the low-carbon dispatch of the integrated energy system focuses on the means of carbon reduction at the source side, while ignoring the low-carbon potential of the load side and the ability of carbon reduction for source-load coordination ...
Shijie XU +3 more
doaj +1 more source
Heat pump heating systemsand low potential heat sources
, 2016 This paper focuses on the application of renewable energy resources in the form of heat pumps and their use in heating systems. As the energy prices are constantly rising, the energy management is currently a very important issue. One of the main reasons is that obtaining the primary energy sources like coal and oil is much more difficult than in the ...
Stefanco, M., Kosicanova, D.
openaire +1 more source