Results 91 to 100 of about 6,254,702 (218)

The low-rank hurdle model

open access: yesCoRR, 2017
A composite loss framework is proposed for low-rank modeling of data consisting of interesting and common values, such as excess zeros or missing values. The methodology is motivated by the generalized low-rank framework and the hurdle method which is commonly used to analyze zero-inflated counts.
openaire   +2 more sources

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

open access: yesFEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber   +7 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

On the geometric interpretation of the nonnegative rank [PDF]

open access: yes
The nonnegative rank of a nonnegative matrix is the minimum number of nonnegative rank-one factors needed to reconstruct it exactly. The problem of determining this rank and computing the corresponding nonnegative factors is difficult; however it has ...
GILLIS, Nicolas, GLINEUR, François
core  

FouRA: Fourier Low-Rank Adaptation

open access: yesAdvances in Neural Information Processing Systems 37
While Low-Rank Adaptation (LoRA) has proven beneficial for efficiently fine-tuning large models, LoRA fine-tuned text-to-image diffusion models lack diversity in the generated images, as the model tends to copy data from the observed training samples. This effect becomes more pronounced at higher values of adapter strength and for adapters with higher ...
Shubhankar Borse   +9 more
openaire   +3 more sources

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

Deep learning through sparse and low-rank modeling /

open access: yes
Deep Learning through Sparse Representation and Low-Rank Modeling bridges classical sparse and low rank models-those that emphasize problem-specific Interpretability-with recent deep network models that have enabled a larger learning capacity and better ...
Huang, Thomas S.editor.   +2 more
core  

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

open access: yesFEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez   +2 more
wiley   +1 more source

Error estimates for SUPG-stabilised Dynamical Low Rank Approximations

open access: yes
We perform an error analysis of a fully discretised Streamline Upwind Petrov Galerkin Dynamical Low Rank (SUPG-DLR) method for random time-dependent advection-dominated problems.
Nobile, Fabio   +1 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

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