Results 91 to 100 of about 9,716,149 (241)

Adopting Generative Artificial Intelligence in Daylighting Design Process

open access: yesJournal of Daylighting
Generative Artificial Intelligence (GenAI) is increasingly adopted in architectural design and widely investigated in the research field. However, several limitations hinder its broader integration into design processes.
Mario Wagdy Berty   +2 more
doaj   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Approximate low-rank factorization with structured factors

open access: yes, 2010
An approximate rank revealing factorization problem with structure constraints on the normalized factors is considered. Examples of structure, motivated by an application in microarray data analysis, are sparsity, nonnegativity, periodicity, and ...
Niranjan, Mahesan, Markovsky, Ivan
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Low-Rank Adaptation of Conditional Diffusion Transformers for Few-Shot Radio-Frequency Signal Generation

open access: yesMathematics
Synthesizing realistic radio-frequency signals is important for data augmentation in wireless systems, yet labeled in-phase/quadrature (I/Q) measurements are expensive to collect, and diffusion models typically demand large per-class training sets.
Qian Li, Xin Xiang, Hu Mao, Yuan Liang
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Parameter-Efficient Adaptation of Qwen2.5 for Aspect-Based Sentiment Analysis Using Low-Rank Adaptation and Parameter-Efficient Fine-Tuning

open access: yesEngineering Proceedings
Aspect-based sentiment analysis (ABSA) plays a vital role in deriving fine-grained sentiment from textual content. As large language models (LLMs) are increasingly adopted for automated data annotation in natural language processing (NLP), concerns have ...
Pei Ying Lim, Chuk Fong Ho, Chi Wee Tan
doaj   +1 more source

Supporting evidence-based adaptation decision-making in South Australia: a synthesis of climate change adaptation research [PDF]

open access: yes, 2013
This research synthesis provides policy-makers and practitioners with an understanding of the building blocks for effective adaptation decision-making, as evidenced through the NCCARF research program.
Laura Cacho   +2 more
core  

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

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