Results 101 to 110 of about 459,286 (299)

QA-LoRA: Quantization-Aware Low-Rank Adaptation of Large Language Models [PDF]

open access: green, 2023
Yuhui Xu   +8 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

RaSA: Rank-Sharing Low-Rank Adaptation

open access: yes
Low-rank adaptation (LoRA) has been prominently employed for parameter-efficient fine-tuning of large language models (LLMs). However, the limited expressive capacity of LoRA, stemming from the low-rank constraint, has been recognized as a bottleneck, particularly in rigorous tasks like code generation and mathematical reasoning.
He, Zhiwei   +9 more
openaire   +2 more sources

Aggregating Low Rank Adapters in Federated Fine-Tuning

open access: yes2024 2nd International Conference on Federated Learning Technologies and Applications (FLTA)
presented at conference https://flta-conference.org/flta-2024-detailed-program/
Trautmann, Evelyn   +2 more
openaire   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Ensembles of Low-Rank Expert Adapters

open access: yes
The training and fine-tuning of large language models (LLMs) often involve diverse textual data from multiple sources, which poses challenges due to conflicting gradient directions, hindering optimization and specialization. These challenges can undermine model generalization across tasks, resulting in reduced downstream performance.
Li, Yinghao   +3 more
openaire   +2 more sources

FLoCoRA: Federated Learning Compression with Low-Rank Adaptation

open access: yes2024 32nd European Signal Processing Conference (EUSIPCO)
Low-Rank Adaptation (LoRA) methods have gained popularity in efficient parameter fine-tuning of models containing hundreds of billions of parameters. In this work, instead, we demonstrate the application of LoRA methods to train small-vision models in Federated Learning (FL) from scratch.
Ribeiro, Lucas Grativol   +4 more
openaire   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

A Survey on Metric Learning for Feature Vectors and Structured Data

open access: yes, 2013
The need for appropriate ways to measure the distance or similarity between data is ubiquitous in machine learning, pattern recognition and data mining, but handcrafting such good metrics for specific problems is generally difficult.
Bellet, Aurélien   +2 more
core  

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